• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

评估可食用黄羊肚菌（Morchella esculenta L. Pers.）子实体和菌丝体提取物的抗氧化、抗炎和神经保护潜力。

Evaluating the antioxidant, anti-inflammatory, and neuroprotective potential of fruiting body and mycelium extracts from edible yellow morel (Morchella esculenta L. Pers.).

作者信息

Haider Rida, Agnello Luisa, Shah Shahid Masood, Sufyan Muhammad, Khan Nimra, Nazir Abdul, Ciaccio Marcello, Rehman Sidra

机构信息

Department of Biotechnology, COMSATS University Islamabad (CUI), Abbottabad Campus, Abbottabad, Pakistan.

Institute of Clinical Biochemistry, Clinical Molecular Medicine, and Clinical Laboratory Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy.

出版信息

J Food Sci. 2025 Jan;90(1):e17619. doi: 10.1111/1750-3841.17619.

DOI:10.1111/1750-3841.17619
PMID:39865641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11771672/
Abstract

SCOPE

This study aimed to assess the antioxidant, anti-inflammatory, and acetylcholinesterase activities of fruiting bodies (FB) and mycelium (M) extracts of Morchella esculenta L. collected from various regions of Pakistan. The samples included Skardu fruiting body (SKFB) and mycelia Skardu (SKM), Malam Jaba fruiting body (MJFB) and Malam Jaba mycelia (MJM), Krair Mansehra fruiting body (KMFB) and Krair Mansehra mycelia (KMM), and Thandiani fruiting body (TFB) and Thandiani mycelia (TM).

METHODS AND RESULTS

The IC values for free radical scavenging activity of all samples revealed that fruiting body SKFB and MJFB of M. esculenta are significantly involved in relieving oxidative stress. Bovine serum albumin conformation destruction assay showed a significantly increased anti-inflammatory activity of SKFB with an IC value of 10.94 ± 0.098 µg/mL. The human red blood cell protection assay showed that TFB has a lower EC value as compared to other samples. KMFB and KMM extracts of M. esculenta showed significantly higher anti-acetylcholinesterase activity compared to the standard drug, donepezil. The lower IC value of M. esculenta extracts suggested higher efficacy for acetylcholinesterase (AChE) inhibition. Enzyme kinetics results showed that KMFB of M. esculenta is a competitive inhibitor, while KMM and Donepezil are noncompetitive AChE inhibitors. Further, molecular docking, physicochemical properties and ADMET analysis of M. esculenta constituents showed smooth drug diffusion and protection against neurodegenerative disorders.

CONCLUSION

This study indicates that M. esculenta extracts may hold significant therapeutic potential for neurodegenerative diseases, opening a path for potential therapeutic strategies.

摘要

范围

本研究旨在评估从巴基斯坦不同地区采集的羊肚菌子实体（FB）和菌丝体（M）提取物的抗氧化、抗炎和乙酰胆碱酯酶活性。样本包括斯卡杜子实体（SKFB）和斯卡杜菌丝体（SKM）、马拉姆贾巴子实体（MJFB）和马拉姆贾巴菌丝体（MJM）、克拉尔曼塞赫拉子实体（KMFB）和克拉尔曼塞赫拉菌丝体（KMM），以及坦迪亚尼子实体（TFB）和坦迪亚尼菌丝体（TM）。

方法与结果

所有样本的自由基清除活性IC值表明，羊肚菌的子实体SKFB和MJFB在缓解氧化应激方面有显著作用。牛血清白蛋白构象破坏试验表明，SKFB的抗炎活性显著增强，IC值为10.94±0.098μg/mL。人体红细胞保护试验表明，与其他样本相比，TFB的EC值较低。羊肚菌的KMFB和KMM提取物显示出比标准药物多奈哌齐更高的抗乙酰胆碱酯酶活性。羊肚菌提取物较低的IC值表明其对乙酰胆碱酯酶（AChE）抑制的疗效更高。酶动力学结果表明，羊肚菌的KMFB是一种竞争性抑制剂，而KMM和多奈哌齐是非竞争性AChE抑制剂。此外，羊肚菌成分的分子对接、理化性质和ADMET分析表明药物扩散顺畅且对神经退行性疾病有保护作用。

结论

本研究表明，羊肚菌提取物可能对神经退行性疾病具有显著的治疗潜力，为潜在的治疗策略开辟了一条道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/64c0073bd82c/JFDS-90-0-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/9ea4a8589419/JFDS-90-0-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/3e97e95783a2/JFDS-90-0-g053.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/578a3ef877a8/JFDS-90-0-g054.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/8fdc18316ca6/JFDS-90-0-g024.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/e6954874878a/JFDS-90-0-g026.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/f4e759d8b260/JFDS-90-0-g041.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/e19f53d652ca/JFDS-90-0-g039.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/234ae243f583/JFDS-90-0-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/5ce73b3909ae/JFDS-90-0-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/9aebb6439d75/JFDS-90-0-g027.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/d8d2928039f5/JFDS-90-0-g025.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/f2b5dc83393c/JFDS-90-0-g038.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/ef8c1ca6c1f4/JFDS-90-0-g040.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/64c0073bd82c/JFDS-90-0-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/9ea4a8589419/JFDS-90-0-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/3e97e95783a2/JFDS-90-0-g053.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/578a3ef877a8/JFDS-90-0-g054.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/8fdc18316ca6/JFDS-90-0-g024.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/e6954874878a/JFDS-90-0-g026.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/f4e759d8b260/JFDS-90-0-g041.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/e19f53d652ca/JFDS-90-0-g039.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/234ae243f583/JFDS-90-0-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/5ce73b3909ae/JFDS-90-0-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/9aebb6439d75/JFDS-90-0-g027.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/d8d2928039f5/JFDS-90-0-g025.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/f2b5dc83393c/JFDS-90-0-g038.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/ef8c1ca6c1f4/JFDS-90-0-g040.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d13/11771672/64c0073bd82c/JFDS-90-0-g012.jpg

相似文献

1
Evaluating the antioxidant, anti-inflammatory, and neuroprotective potential of fruiting body and mycelium extracts from edible yellow morel (Morchella esculenta L. Pers.).评估可食用黄羊肚菌（Morchella esculenta L. Pers.）子实体和菌丝体提取物的抗氧化、抗炎和神经保护潜力。
J Food Sci. 2025 Jan;90(1):e17619. doi: 10.1111/1750-3841.17619.
2
A polysaccharide from Morchella esculenta mycelia: Structural characterization and protective effect on antioxidant stress on PC12 cells against HO-induced oxidative damage.一种来自羊肚菌菌丝体的多糖：结构表征及其对PC12细胞抗氧化应激抵抗HO诱导的氧化损伤的保护作用。
Int J Biol Macromol. 2025 Apr;298:139886. doi: 10.1016/j.ijbiomac.2025.139886. Epub 2025 Jan 14.
3
Antioxidative, antifungal, cytotoxic and antineurodegenerative activity of selected Trametes species from Serbia.塞尔维亚部分硫色多孔菌的抗氧化、抗真菌、细胞毒性和神经退行性疾病活性研究。
PLoS One. 2018 Aug 31;13(8):e0203064. doi: 10.1371/journal.pone.0203064. eCollection 2018.
4
Structural characterization, in vitro and in vivo antioxidant activities of a heteropolysaccharide from the fruiting bodies of Morchella esculenta.从羊肚菌子实体中提取的杂多糖的结构表征、体外和体内抗氧化活性。
Carbohydr Polym. 2018 Sep 1;195:29-38. doi: 10.1016/j.carbpol.2018.04.069. Epub 2018 Apr 21.
5
Evaluation of free radical scavenging activity of morel mushroom, Morchella esculenta mycelia: a potential source of therapeutically useful antioxidants.评估羊肚菌菌丝体清除自由基的活性：一种有治疗潜力的抗氧化剂的潜在来源。
Pharm Biol. 2010 Apr;48(4):453-60. doi: 10.3109/13880200903170789.
6
Distribution of Mycelia of Morchella esculenta in Wild Field.野生环境中羊肚菌菌丝体的分布
Curr Microbiol. 2019 Feb;76(2):168-172. doi: 10.1007/s00284-018-1603-0. Epub 2018 Nov 28.
7
Aqueous-ethanolic extract of morel mushroom mycelium Morchella esculenta, protects cisplatin and gentamicin induced nephrotoxicity in mice.羊肚菌菌丝体的水乙醇提取物可保护小鼠免受顺铂和庆大霉素诱导的肾毒性。
Food Chem Toxicol. 2008 Sep;46(9):3193-9. doi: 10.1016/j.fct.2008.07.007. Epub 2008 Jul 22.
8
Antioxidant, Anti-Inflammatory, and Antitumor Activities of Cultured Mycelia and Fruiting Bodies of the Elm Oyster Mushroom, Hypsizygus ulmarius (Agaricomycetes).榆黄蘑（伞菌纲）培养菌丝体和子实体的抗氧化、抗炎及抗肿瘤活性
Int J Med Mushrooms. 2016;18(3):235-44. doi: 10.1615/IntJMedMushrooms.v18.i3.60.
9
Mycochemical profile and health-promoting effects of morel mushroom Morchella esculenta (L.) - A review.羊肚菌 Morchella esculenta (L.) 的化学成分分析及保健作用：综述。
Food Res Int. 2022 Sep;159:111571. doi: 10.1016/j.foodres.2022.111571. Epub 2022 Jun 25.
10
Isolation, Characterization, and Medicinal Potential of Polysaccharides of .. 的多糖的分离、表征和药用潜力
Molecules. 2021 Mar 8;26(5):1459. doi: 10.3390/molecules26051459.

引用本文的文献

1
Structural Bioinformatics Applied to Acetylcholinesterase Enzyme Inhibition.结构生物信息学在乙酰胆碱酯酶抑制中的应用
Int J Mol Sci. 2025 Apr 17;26(8):3781. doi: 10.3390/ijms26083781.
2
Microbial Community Response and Assembly Process of Yellow Sand Matrix in a Desert Marginal Zone Under Cultivation.荒漠边缘区黄沙基质在耕作条件下的微生物群落响应及组装过程
Microorganisms. 2025 Apr 16;13(4):921. doi: 10.3390/microorganisms13040921.

本文引用的文献

1
Food and Antioxidant Supplements with Therapeutic Properties of Morchella esculenta (Ascomycetes): A Review.《具有药用特性的羊肚菌（子囊菌）的食物和抗氧化补充剂：综述》。
Int J Med Mushrooms. 2023;25(9):11-29. doi: 10.1615/IntJMedMushrooms.2023049147.
2
Norbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFκB, MAPK and STAT3 activation and blocking metabolic reprogramming.诺贝灵抑制 NFκB、MAPK 和 STAT3 的激活和代谢重编程，从而防止 LPS 诱导的巨噬细胞炎症反应。
Front Immunol. 2023 May 12;14:1117638. doi: 10.3389/fimmu.2023.1117638. eCollection 2023.
3
Antioxidant Compounds from Edible Mushrooms as Potential Candidates for Treating Age-Related Neurodegenerative Diseases.
食用蘑菇中的抗氧化化合物作为治疗与年龄相关的神经退行性疾病的潜在候选物。
Nutrients. 2023 Apr 15;15(8):1913. doi: 10.3390/nu15081913.
4
Cultivation, nutritional value, bioactive compounds of morels, and their health benefits: A systematic review.羊肚菌的栽培、营养价值、生物活性成分及其健康益处：一项系统综述
Front Nutr. 2023 Mar 17;10:1159029. doi: 10.3389/fnut.2023.1159029. eCollection 2023.
5
Immunomodulatory function and anti-tumor mechanism of natural polysaccharides: A review.天然多糖的免疫调节功能及抗肿瘤机制研究进展。
Front Immunol. 2023 Mar 9;14:1147641. doi: 10.3389/fimmu.2023.1147641. eCollection 2023.
6
Piracetam as a Therapeutic Agent for Doxorubicin-Induced Cognitive Deficits by Enhancing Cholinergic Functions and Reducing Neuronal Inflammation, Apoptosis, and Oxidative Stress in Rats.吡拉西坦作为一种治疗药物，通过增强胆碱能功能、减轻大鼠神经元炎症、细胞凋亡和氧化应激来改善阿霉素诱导的认知缺陷。
Pharmaceuticals (Basel). 2022 Dec 14;15(12):1563. doi: 10.3390/ph15121563.
7
Anti-ovarian cancer potential, in silico studies, and anti-Alzheimer's disease effects of some natural compounds as cholinesterase inhibitors.抗卵巢癌潜力、计算机模拟研究以及几种作为胆碱酯酶抑制剂的天然化合物的抗老年痴呆症作用。
Biotechnol Appl Biochem. 2023 Jun;70(3):1085-1099. doi: 10.1002/bab.2422. Epub 2022 Dec 27.
8
Conventional Versus New Treatment: Comparing the Effects of Acetylcholinesterase Inhibitors and N-Methyl-D-Aspartate Receptor Antagonist With Aducanumab.传统疗法与新疗法：比较乙酰胆碱酯酶抑制剂和N-甲基-D-天冬氨酸受体拮抗剂与阿杜卡单抗的效果
Cureus. 2022 Nov 3;14(11):e31065. doi: 10.7759/cureus.31065. eCollection 2022 Nov.
9
Pyridine-N-Oxide Alkaloids from and Their Synthetic Disulfide Analogs as Potential Drug Candidates against : A Molecular Docking, QSBAR, and ADMET Prediction Approach.和及其合成二硫化物类似物中的吡啶-N-氧化物生物碱作为抗 的潜在药物候选物：一种基于分子对接、QSAR 和 ADMET 预测的方法。
Biomed Res Int. 2022 Oct 7;2022:6261528. doi: 10.1155/2022/6261528. eCollection 2022.
10
Mycochemical profile and health-promoting effects of morel mushroom Morchella esculenta (L.) - A review.羊肚菌 Morchella esculenta (L.) 的化学成分分析及保健作用：综述。
Food Res Int. 2022 Sep;159:111571. doi: 10.1016/j.foodres.2022.111571. Epub 2022 Jun 25.