Tran Quyen H N, Nguyen Huong T M, Nguyen Thuy L T, Sichaem Jirapast, Do Lien T M
Institute of Environment-Energy Technology, Sai Gon University, Ho Chi Minh City, Vietnam.
Department of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, Vietnam.
Chem Biodivers. 2025 Jun;22(6):e202403406. doi: 10.1002/cbdv.202403406. Epub 2025 Feb 9.
The chemical investigation of the fruits of Garcinia schomburgkiana growing in Vietnam led to the isolation of a new anofinic acid derivative, 5-hydroxy-8-methoxyanofinic acid (1), a new xanthone, xanthoschome C (2), and a known synthetic phenolic analog, 4-(2-hydroxybenzyl)-2-(4-hydroxybenzyl) phenol (3), along with seven known xanthones (4-10). The structures of all isolated compounds were determined using spectroscopic techniques (nuclear magnetic resonance and mass spectrometry), in conjunction with a comparison to existing literature data. All isolated compounds were assessed for their α-glucosidase inhibitory activity and showed significant inhibition, with half-maximal inhibitory concentration (IC) values ranging from 12.1 to 65.7 µM, surpassing the potency of the positive control, acarbose (IC 179 ± 6.02 µM). Among them, compound 8 exhibited the strongest inhibitory activity, with an IC value of 12.1 ± 0.44 µM.
对生长在越南的山竹子果实进行化学研究，从中分离出一种新的阿诺菲尼酸衍生物5-羟基-8-甲氧基阿诺菲尼酸（1）、一种新的氧杂蒽酮类化合物氧杂蒽酮C（2）、一种已知的合成酚类类似物4-(2-羟基苄基)-2-(4-羟基苄基)苯酚（3），以及七种已知的氧杂蒽酮类化合物（4 - 10）。所有分离得到的化合物结构均通过光谱技术（核磁共振和质谱）并与现有文献数据进行比较来确定。对所有分离得到的化合物进行了α-葡萄糖苷酶抑制活性评估，结果显示它们均具有显著抑制作用，半数抑制浓度（IC）值在12.1至65.7 μM之间，超过了阳性对照阿卡波糖的效力（IC 179 ± 6.02 μM）。其中，化合物8表现出最强的抑制活性，IC值为12.1 ± 0.44 μM。
