Finlay G J, Booth R J, Marbrook J
Aust J Exp Biol Med Sci. 1979 Dec;57(6):597-602. doi: 10.1038/icb.1979.63.
Cultures of human tonsillar lymphocytes stimulated by pokeweed mitogen in the presence of hydrocortisone succinate generate more sheep red blood cell-specific plaque-forming cells than when the hydrocortisone is absent. Such enhancement is even more marked when sheep red blood cells and pokeweed mitogen are present in cultures. This contrasts with the inability of sheep red blood cells to enhance pokeweed mitogen-stimulated response in cultures lacking hydrocortisone. Hydrocortisone causes greater enhancement when the concentration of cells in culture is high than when it is low. These data are consistent with hydrocortisone inhibiting the activity of suppressor cells which would otherwise mask helper effects.
在存在琥珀酸氢化可的松的情况下，由商陆有丝分裂原刺激的人扁桃体淋巴细胞培养物比不存在氢化可的松时产生更多的绵羊红细胞特异性空斑形成细胞。当培养物中存在绵羊红细胞和商陆有丝分裂原时，这种增强更为明显。这与在缺乏氢化可的松的培养物中绵羊红细胞无法增强商陆有丝分裂原刺激的反应形成对比。当培养物中细胞浓度高时，氢化可的松引起的增强作用比细胞浓度低时更大。这些数据与氢化可的松抑制抑制性细胞的活性一致，否则抑制性细胞会掩盖辅助效应。
