Speelman J D, ter Schegget J, Bots G T, Stam J, Verbeeten B
Clin Neurol Neurosurg. 1985;87(1):27-33. doi: 10.1016/0303-8467(85)90062-9.
The case of a 40-year-old homosexual male with A.I.D.S. (Acquired Immune Deficiency Syndrome) and P.M.L. (Progressive Multifocal Leukoencephalopathy) is described. The importance of a brain biopsy for diagnostic procedures, especially in the case of a patient with A.I.D.S. is stressed. The diagnosis P.M.L. has been made by means of light- and electronic microscopical examination, and the presence of JCV-DNA in the brain tissue has been confirmed by dot hybridization. Various antiviral treatments did not show any effect on the course of the P.M.L.
本文描述了一名40岁患有艾滋病（获得性免疫缺陷综合征）和进行性多灶性白质脑病（PML）的同性恋男性病例。强调了脑活检在诊断过程中的重要性，特别是对于艾滋病患者。通过光镜和电子显微镜检查做出了PML的诊断，并且通过斑点杂交证实了脑组织中存在JC病毒DNA。各种抗病毒治疗对PML的病程均无任何效果。
