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Metabolic restraining of epigenetic modifications promotes cardiomyocyte proliferation.

作者信息

Liu Xiuxiu, Zhou Bin

机构信息

New Cornerstone Science Laboratory, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, Zhejiang 310024, China.

出版信息

Life Metab. 2023 Dec 1;3(1):load047. doi: 10.1093/lifemeta/load047. eCollection 2024 Feb.

DOI:10.1093/lifemeta/load047
PMID:39871881
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11749453/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d10f/11749453/e59fa524e0c0/load047_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d10f/11749453/e59fa524e0c0/load047_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d10f/11749453/e59fa524e0c0/load047_fig1.jpg

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本文引用的文献

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Inhibition of fatty acid oxidation enables heart regeneration in adult mice.脂肪酸氧化抑制可促进成年小鼠的心脏再生。
Nature. 2023 Oct;622(7983):619-626. doi: 10.1038/s41586-023-06585-5. Epub 2023 Sep 27.
2
Cardiac Energy Metabolism in Heart Failure.心力衰竭中的心脏能量代谢。
Circ Res. 2021 May 14;128(10):1487-1513. doi: 10.1161/CIRCRESAHA.121.318241. Epub 2021 May 13.
3
Mitochondrial Substrate Utilization Regulates Cardiomyocyte Cell Cycle Progression.线粒体底物利用调节心肌细胞细胞周期进程。
Nat Metab. 2020 Feb;2(2):167-178. Epub 2020 Feb 20.
4
Genetic Lineage Tracing of Nonmyocyte Population by Dual Recombinases.双重组酶对非心肌细胞群体的遗传谱系追踪。
Circulation. 2018 Aug 21;138(8):793-805. doi: 10.1161/CIRCULATIONAHA.118.034250.
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Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration.调控细胞周期以刺激成体心肌细胞增殖和心脏再生。
Cell. 2018 Mar 22;173(1):104-116.e12. doi: 10.1016/j.cell.2018.02.014. Epub 2018 Mar 1.
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Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair.活细胞筛选平台确定过氧化物酶体增殖物激活受体δ为心肌细胞增殖和心脏修复的调节因子。
Cell Res. 2017 Aug;27(8):1002-1019. doi: 10.1038/cr.2017.84. Epub 2017 Jun 16.
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Cardiac regeneration strategies: Staying young at heart.心脏再生策略：保持心脏年轻。
Science. 2017 Jun 9;356(6342):1035-1039. doi: 10.1126/science.aam5894. Epub 2017 Jun 8.
8
Hypoxia induces heart regeneration in adult mice.缺氧诱导成年小鼠心脏再生。
Nature. 2017 Jan 12;541(7636):222-227. doi: 10.1038/nature20173. Epub 2016 Oct 31.
9
Mammalian heart renewal by pre-existing cardiomyocytes.哺乳动物的心肌再生由预先存在的心肌细胞完成。
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Evidence for cardiomyocyte renewal in humans.人类心肌细胞更新的证据。
Science. 2009 Apr 3;324(5923):98-102. doi: 10.1126/science.1164680.