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感染与代谢功能障碍相关脂肪性肝炎之间关联的潜在机制及治疗前景

Potential mechanisms and therapeutic prospects of the association between infection and metabolic dysfunction-associated steatohepatitis.

作者信息

Gou Guo-E, Li Ting, Liu Chen-Rui, Meng Ting, Li Ya-Ping

机构信息

Department of Infectious Diseases, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an 710004, Shaanxi Province, China.

出版信息

World J Hepatol. 2025 Jan 27;17(1):101798. doi: 10.4254/wjh.v17.i1.101798.

DOI:10.4254/wjh.v17.i1.101798
PMID:39871896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11736473/
Abstract

() infection is a known inducer of various gastrointestinal diseases, including gastritis, gastric ulcers, and gastric cancer. However, in recent years, research on the potential association between infection and metabolic dysfunction-associated steatohepatitis (MASH) has been scarce. This large-scale multicenter study, covering more than 360 hospitals across 26 medical systems in the United States, systematically evaluated the association between infection and MASH. This paper reviews the innovative aspects of this study, discusses its significance in the current research field of and liver diseases, analyzes potential molecular mechanisms, and suggests future research directions and therapeutic prospects.

摘要

（）感染是多种胃肠道疾病的已知诱因，包括胃炎、胃溃疡和胃癌。然而，近年来，关于（）感染与代谢功能障碍相关脂肪性肝炎（MASH）之间潜在关联的研究一直很少。这项大规模多中心研究覆盖了美国26个医疗系统的360多家医院，系统评估了（）感染与MASH之间的关联。本文回顾了该研究的创新之处，讨论了其在当前（）和肝脏疾病研究领域的意义，分析了潜在的分子机制，并提出了未来的研究方向和治疗前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cb5/11736473/0b469345fef8/101798-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cb5/11736473/0b469345fef8/101798-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cb5/11736473/0b469345fef8/101798-g001.jpg

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本文引用的文献

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World J Hepatol. 2024 Oct 27;16(10):1169-1176. doi: 10.4254/wjh.v16.i10.1169.
2
The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver disease.幽门螺杆菌感染与 rs738409PNPLA3 在代谢功能障碍相关脂肪性肝病中的相互作用。
PLoS One. 2024 Sep 23;19(9):e0310361. doi: 10.1371/journal.pone.0310361. eCollection 2024.
3
Epidemiology of Gastric Cancer-Changing Trends and Global Disparities.
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Cancers (Basel). 2024 Aug 24;16(17):2948. doi: 10.3390/cancers16172948.
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Bidirectional relationship between infection and nonalcoholic fatty liver disease: insights from a comprehensive meta-analysis.感染与非酒精性脂肪性肝病之间的双向关系：一项全面荟萃分析的见解
Front Nutr. 2024 Aug 5;11:1410543. doi: 10.3389/fnut.2024.1410543. eCollection 2024.
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NAFLD (MASLD)/NASH (MASH): Does It Bother to Label at All? A Comprehensive Narrative Review.非酒精性脂肪性肝病（MASLD）/非酒精性脂肪性肝炎（MASH）：是否有必要进行标记？全面的叙述性综述。
Int J Mol Sci. 2024 Aug 2;25(15):8462. doi: 10.3390/ijms25158462.
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