Bowah Collins Saa, Nhungo Charles John, Mavundla Jabu A, Mwanga Ally H, Mkony Charles A, Gaskill Cameron E
Department of Surgery, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Department of Surgery, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Int J Surg Case Rep. 2025 Feb;127:110965. doi: 10.1016/j.ijscr.2025.110965. Epub 2025 Jan 27.
Gallbladder cancer (GBC) is a rare but aggressive malignancy, accounting for most biliary tract cancers. It typically presents at an advanced stage, leading to a poor prognosis, with a mean survival of six months and a five-year survival rate of 17.6 %. Early detection is critical due to its insidious onset and rapid progression.
We report a case of a 46-year-old African male who presented with a two-week history of colicky abdominal pain. Diagnostic imaging revealed a gallbladder mass, and the patient underwent surgical resection followed by adjuvant therapy. Postoperative recovery was initially satisfactory; however, 18 months later, the patient developed peritoneal carcinomatosis and succumbed to the disease.
This case highlights the challenges of managing GBC in resource-limited settings, where late-stage presentation is common. Early surgical intervention remains the mainstay of potentially curative treatment. Adjuvant therapies may improve outcomes but are often less effective in advanced disease stages.
Early detection and surgical management are pivotal for improving survival outcomes in gallbladder cancer. This case emphasizes the need for heightened clinical awareness and improved diagnostic capabilities in resource-constrained environments.
胆囊癌（GBC）是一种罕见但侵袭性强的恶性肿瘤，占大多数胆道癌。它通常在晚期出现，导致预后不良，平均生存期为六个月，五年生存率为17.6%。由于其起病隐匿且进展迅速，早期检测至关重要。
我们报告一例46岁非洲男性患者，有两周的绞痛性腹痛病史。诊断性影像学检查发现胆囊肿物，患者接受了手术切除及辅助治疗。术后恢复起初令人满意；然而，18个月后，患者出现腹膜癌转移并死于该疾病。
该病例凸显了在资源有限环境中管理胆囊癌的挑战，在这些环境中晚期表现很常见。早期手术干预仍然是潜在治愈性治疗的主要手段。辅助治疗可能改善预后，但在疾病晚期往往效果较差。
早期检测和手术管理对于改善胆囊癌的生存结局至关重要。该病例强调了在资源受限环境中提高临床意识和改善诊断能力的必要性。
