Guo Huiqi, Zhao Xia, Duan Yanping, Shi Jingzhuan
Shaanxi Key Laboratory of Catalysis, School of Chemistry and Environment Science, Shaanxi University of Technology, No.1 East 1st Ring Road, Hanzhong, Shaanxi 723001, PR China.
Shaanxi Key Laboratory of Catalysis, School of Chemistry and Environment Science, Shaanxi University of Technology, No.1 East 1st Ring Road, Hanzhong, Shaanxi 723001, PR China.
Colloids Surf B Biointerfaces. 2025 May;249:114534. doi: 10.1016/j.colsurfb.2025.114534. Epub 2025 Jan 25.
The advantages of large surface area, high volume ratio, good biocompatibility, and controllable surface functionalization make hollow mesoporous silica nanoparticles (HMSNs) an ideal drug carrier. HMSNs can achieve high efficiency, targeting, and controlled release by adjusting the microstructure and surface modification of its particles, which makes it broad application prospects in the field of medical therapy, especially in cancer therapy. Numerous studies have shown that preparation method, shape, particle size, hollow inner diameter, aperture and wall thickness of the HMSNs, the characteristics of the drugs, the interaction between the drugs and the carriers, and the external environment all closely affect the drug delivery, release, and efficacy. The external environment includes temperature, pH value, light intensity, magnetic field intensity, enzyme type and concentration, etc. This review summarizes the research progress of HMSNs as carrier materials in the past five years, analyzes the existing problems in the application process and presents the development prospects of HMSNs.
大比表面积、高体积比、良好的生物相容性以及可控的表面功能化等优点，使中空介孔二氧化硅纳米粒子（HMSNs）成为理想的药物载体。通过调节其颗粒的微观结构和表面修饰，HMSNs能够实现高效、靶向和控释，这使其在医学治疗领域，尤其是癌症治疗领域具有广阔的应用前景。大量研究表明，HMSNs的制备方法、形状、粒径、中空内径、孔径和壁厚、药物特性、药物与载体之间的相互作用以及外部环境等，均密切影响药物递送、释放和疗效。外部环境包括温度、pH值、光照强度、磁场强度、酶的类型和浓度等。本文综述了过去五年中HMSNs作为载体材料的研究进展，分析了应用过程中存在的问题，并展望了HMSNs的发展前景。
