Zesch A, Bauer E
Derm Beruf Umwelt. 1985;33(1):15-20.
Since topical vehicles are partly responsible for the effects of active agents--both the wanted and the unwanted effects--attempt was made to obtain quantitative data on the possible penetration of cetyl alcohol contained in an aqueous hydrophilie cream (DAB 8) and in a wool fat alcohol ointment (lanoline) (DAB 8). Also the behaviour of the long-chained hydrocarbon, paraffin (octadecan), in these vehicles and in petrolatum (DAB 8) was studied. We found that the emulsifying agent in a W/O emulsion was detectable in the epidermis in low concentrations after 100 min, but the same agent in O/W emulsions only after 1000 min. It is, therefore, unlikely that cetyl alcohol penetrates the intact skin in allergicologically relevant concentrations. However, with diseased skin, a marked percutaneous absorption of cetyl alcohol, but not with paraffin, must be expected.
由于局部用药载体对活性剂的作用（包括预期作用和非预期作用）负有部分责任，因此有人尝试获取有关水性亲水性乳膏（德国药典8版）和羊毛脂醇软膏（羊毛脂）（德国药典8版）中所含十六醇可能渗透情况的定量数据。此外，还研究了长链烃石蜡（十八烷）在这些载体以及凡士林（德国药典8版）中的行为。我们发现，油包水型乳剂中的乳化剂在100分钟后能在表皮中检测到低浓度存在，但水包油型乳剂中的同一乳化剂在1000分钟后才能检测到。因此，十六醇以过敏学相关浓度穿透完整皮肤的可能性不大。然而，对于患病皮肤，必须预期会有明显的十六醇经皮吸收，但石蜡不会。
