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评估温度动态变化:一项关于钬激光与铥激光光纤治疗肾结石的单中心前瞻性随机试验研究。

Evaluating temperature dynamics: a single-center prospective randomized pilot study of holmium versus thulium laser fiber for renal stones.

作者信息

Patel Vaibhavkumar, Raghuvanshi Kshitij, Chaudhari Rajeev

机构信息

Department of Urology, Ruby Hall Clinic, Pune, India.

出版信息

World J Urol. 2025 Jan 28;43(1):91. doi: 10.1007/s00345-025-05466-y.

Abstract

BACKGROUND

We aimed to evaluate and compare the rise in the temperature for the safety of the kidney parenchyma on firing the Holmium: Yttrium Aluminium Garnet laser and the Thulium Fiber Laser during laser lithotripsy in humans.

METHOD

We included 30 pre-stented patients with renal calculi undergoing Retrograde intra-renal surgery. They were randomized into two groups - 15 patients underwent holmium laser lithotripsy and 15 patients underwent TFL laser lithotripsy. We used Philips paediatric esophageal probe to measure rise in temperature on firing holmium or TFL laser with irrigation at 10 ml/min and pressure at 100 mmHg. Different laser settings were used.

RESULT

The mean size of the calculi was 0.8 mm. The rise in temperature with holmium and TFL lasers depended on the firing time and irrigation flow, keeping power constant. On continuous firing for 10s, 20s, and 30s, the average rise in temperature went up to 28.67 °C, 29.70 °C, and 37.17 °C with holmium and with TFL it was 28.77 °C, 29.83 °C, and 37.62 °C, respectively. The difference in rise in temperature between two groups was statistically insignificant with p-values > 0.05. The maximum temperature reached with TFL was 39.4 °C with a 30s lasing time, and that with Ho: YAG was 38.9 °C.

CONCLUSIONS

The rise in temperature was almost equivalent with holmium and TFL. Hence, both Ho: YAG and TFL can be safely used in laser lithotripsy. Adequate irrigation is a must during the surgery. The continuous lasing time should be strictly restricted to less than 20s.

摘要

背景

我们旨在评估和比较在人体激光碎石术中使用钬:钇铝石榴石激光和铥光纤激光时,为保护肾实质而产生的温度升高情况。

方法

我们纳入了30例接受逆行性肾内手术的预置支架肾结石患者。他们被随机分为两组——15例患者接受钬激光碎石术,15例患者接受铥光纤激光碎石术。我们使用飞利浦小儿食管探头,在以10毫升/分钟的速度冲洗且压力为100毫米汞柱的情况下,测量发射钬激光或铥光纤激光时的温度升高情况。使用了不同的激光设置。

结果

结石的平均大小为0.8毫米。在功率恒定的情况下,钬激光和铥光纤激光产生的温度升高取决于发射时间和冲洗流量。连续发射10秒、20秒和30秒时,钬激光导致的平均温度升高分别达到28.67℃、29.70℃和37.17℃,铥光纤激光导致的平均温度升高分别为28.77℃、29.83℃和37.62℃。两组之间温度升高的差异无统计学意义,p值>0.05。铥光纤激光在发射30秒时达到的最高温度为39.4℃,钬:钇铝石榴石激光达到的最高温度为38.9℃。

结论

钬激光和铥光纤激光导致的温度升高几乎相当。因此,钬:钇铝石榴石激光和铥光纤激光均可安全用于激光碎石术。手术期间必须进行充分冲洗。连续发射时间应严格限制在20秒以内。

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