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2008年至2023年芬兰双胎妊娠的新生儿结局。

Neonatal outcomes in twin pregnancies in Finland from 2008 to 2023.

作者信息

Kuitunen Ilari

机构信息

Institute of Clinical Medicine and Department of Pediatrics, University of Eastern Finland, Kuopio, Finland.

Department of Pediatrics, Kuopio University Hospital, Puijonlaaksontie 2, 70210, Kuopio, Finland.

出版信息

Eur J Pediatr. 2025 Jan 28;184(2):158. doi: 10.1007/s00431-025-05996-y.

Abstract

UNLABELLED

Twin pregnancies are associated with higher risks of adverse maternal and neonatal outcomes compared to singleton pregnancies. This retrospective nationwide cohort study analyzed trends in twin pregnancy outcomes in Finland from 2008 to 2023 using data from the Finnish Medical Birth Register. Outcomes assessed included perinatal mortality, stillbirths, neonatal mortality, neonatal intensive care unit (NICU) admissions, and hospitalization rates at one week of age. A total of 23,588 twin births were included, with an overall stillbirth rate of 9.0 per 1000 and a perinatal mortality rate of 16.0 per 1000. Neonatal mortality rates declined significantly, with term twins showing a rate of 0.9 per 1000 and preterm twins 4.6 per 1000 in the latest years of 2022-2023. NICU admission rates remained stable for preterm twins but showed an increasing trend for term twins. The rate of hospitalized neonates at the age of seven days decreased over time.

CONCLUSION

These trends align with improved antenatal care and Finland's reputation for low neonatal mortality. However, increasing maternal age and obesity rates may contribute to rising NICU admissions in term twins. The study highlights the need for continuous monitoring of neonatal outcomes to ensure high standards of care in the context of declining fertility and delivery rates in Finland.

WHAT IS KNOWN

• Twin pregnancies are associated with higher risks of adverse maternal and neonatal outcomes compared to singleton pregnancies. • Finland has one of the lowest neonatal mortality rates globally.

WHAT IS NEW

• Neonatal mortality rates declined significantly both in term and preterm twins from 2008 to 2023. • NICU admission rates remained stable for preterm twins but showed an increasing trend for term twins.

摘要

未标注

与单胎妊娠相比,双胎妊娠的孕产妇和新生儿不良结局风险更高。这项全国性回顾性队列研究利用芬兰医疗出生登记处的数据,分析了2008年至2023年芬兰双胎妊娠结局的趋势。评估的结局包括围产期死亡率、死产、新生儿死亡率、新生儿重症监护病房(NICU)入院率以及1周龄时的住院率。共纳入23588例双胎分娩,总体死产率为每1000例9.0例,围产期死亡率为每1000例16.0例。新生儿死亡率显著下降,在2022 - 2023年的最近几年中,足月双胎的死亡率为每1000例0.9例,早产双胎为每1000例4.6例。早产双胎的NICU入院率保持稳定,但足月双胎呈上升趋势。7日龄新生儿的住院率随时间下降。

结论

这些趋势与产前护理的改善以及芬兰低新生儿死亡率的声誉相符。然而,产妇年龄增加和肥胖率上升可能导致足月双胎的NICU入院率上升。该研究强调了在芬兰生育率和分娩率下降的背景下,持续监测新生儿结局以确保高标准护理的必要性。

已知信息

• 与单胎妊娠相比,双胎妊娠与更高的孕产妇和新生儿不良结局风险相关。• 芬兰是全球新生儿死亡率最低的国家之一。

新发现

• 2008年至2023年期间,足月和早产双胎的新生儿死亡率均显著下降。• 早产双胎的NICU入院率保持稳定,但足月双胎呈上升趋势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e653/11775026/120bf0b732bc/431_2025_5996_Fig1_HTML.jpg

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