一次有氧运动后1型糖尿病患者循环内皮祖细胞和炎症标志物的变化

Circulating endothelial progenitor cells and inflammatory markers in type 1 diabetes after an acute session of aerobic exercise.

作者信息

Bock Patrícia Martins, Monteiro Raíssa Borges, Maraschin Clara Krummenauer, Alegretti Ana Paula, Farias Mariela Granero, Spagnol Fabiane, Lopez Patricia Luciana da Costa, Santos Lucas Porto, Helal Lucas, Moraes Ruy Silveira, Umpierre Daniel, Schaan Beatriz D

机构信息

Instituto Nacional de Ciência e Tecnologia para Avaliação de Tecnologias em Saúde Hospital de Clínicas de Porto Alegre Porto AlegreRS Brasil Instituto Nacional de Ciência e Tecnologia para Avaliação de Tecnologias em Saúde (IATS) - CNPq/Brasil, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brasil.

Universidade Federal do Rio Grande Rio GrandeRS Brasil Universidade Federal do Rio Grande, Rio Grande, RS, Brasil.

出版信息

Arch Endocrinol Metab. 2024 Nov 6;68(Spec Issue):e230499. doi: 10.20945/2359-4292-2023-0499. eCollection 2024.

DOI:10.20945/2359-4292-2023-0499

PMID:39876965

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11771752/

Abstract

OBJECTIVE

To determine circulating endothelial progenitor cells (EPC) counts and levels of inflammatory markers in individuals with and without type 1 diabetes mellitus (T1DM) in response to an intense aerobic exercise session.

SUBJECTS AND METHODS

In total, 15 adult men with T1DM and 15 healthy individuals underwent a 30-minute aerobic exercise session on a cycle ergometer at 60% of the peak heart rate. The EPC count (CD45/CD34/KDR), tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) levels were measured before and 60 minutes after the session.

RESULTS

We found no difference within or between groups regarding EPC counts before and after the aerobic exercise: healthy individuals, 0.02% change (95% confidence interval [CI] -0.04%-0.08%); individuals with T1DM, 0.00% (95%CI -0.01%-0.01%). We also found no difference in TNF-α levels before and after exercise in healthy individuals (210.2, interquartile range [IQR] 142.1-401.2 pg/mL and 191.3, IQR 136.4-350.5 pg/mL, respectively) and in patients with T1DM (463.8, IQR 201.4-4306.0 pg/mL and 482.7, IQR 143.8-4304.3 pg/mL, respectively). Similarly, no difference in IL-6 levels was observed before and after exercise in healthy individuals (148.2, IQR 147.5-148.6 pg/mL and 148.2, IQR 147.7-148.6 pg/mL, respectively) and individuals with T1DM (147.2, IQR 145.9-147.7 pg/mL and 147.2, IQR 146.8-147.8 pg/mL, respectively).

CONCLUSIONS

Patients with T1DM and healthy controls had comparable EPC responses to aerobic exercise, most likely due to the absence of a chronic inflammatory state.

摘要

目的

测定1型糖尿病（T1DM）患者和非T1DM患者在进行一次剧烈有氧运动后循环内皮祖细胞（EPC）计数及炎症标志物水平。

受试者与方法

总共15名成年男性T1DM患者和15名健康个体在功率自行车上进行了30分钟的有氧运动，运动强度为峰值心率的60%。在运动前和运动后60分钟测量EPC计数（CD45/CD34/KDR）、肿瘤坏死因子-α（TNF-α）和白细胞介素6（IL-6）水平。

结果

我们发现在有氧运动前后，组内和组间的EPC计数均无差异：健康个体，变化0.02%（95%置信区间[CI] -0.04% - 0.08%）；T1DM患者，变化0.00%（95%CI -0.01% - 0.01%）。我们还发现，健康个体运动前后的TNF-α水平无差异（分别为210.2，四分位间距[IQR] 142.1 - 401.2 pg/mL和191.3，IQR 136.4 - 350.5 pg/mL），T1DM患者运动前后的TNF-α水平也无差异（分别为463.8，IQR 201.4 - 4306.0 pg/mL和482.7，IQR 143.8 - 4304.3 pg/mL）。同样，健康个体运动前后的IL-6水平无差异（分别为148.2，IQR 147.5 - 148.6 pg/mL和148.2，IQR 147.7 - 148.6 pg/mL），T1DM患者运动前后的IL-6水平也无差异（分别为147.2，IQR 145.9 - 147.7 pg/mL和147.2，IQR 146.8 - 147.8 pg/mL）。