Mätlik Kärt, Govek Eve-Ellen, Hatten Mary E
Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10065, USA;
Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia.
Genes Dev. 2025 Apr 1;39(7-8):428-444. doi: 10.1101/gad.352306.124.
Neuronal maturation is guided by changes in the chromatin landscape that control developmental gene expression programs. Histone bivalency, the co-occurrence of activating and repressive histone modifications, has emerged as an epigenetic feature of developmentally regulated genes during neuronal maturation. Although initially associated with early embryonic development, recent studies have shown that histone bivalency also exists in differentiated and mature neurons. In this review, we discuss methods to study bivalency in specific populations of neurons and summarize emerging studies on the function of bivalency in central nervous system neuronal maturation and in adult neurons.
神经元成熟受染色质景观变化的引导，这些变化控制着发育基因表达程序。组蛋白双价性，即激活和抑制性组蛋白修饰的共同出现，已成为神经元成熟过程中发育调控基因的一种表观遗传特征。尽管最初与早期胚胎发育相关，但最近的研究表明，组蛋白双价性也存在于分化成熟的神经元中。在这篇综述中，我们讨论了研究特定神经元群体中双价性的方法，并总结了关于双价性在中枢神经系统神经元成熟和成年神经元中功能的新研究。
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