Wang Xiaojing, Ishimatsu Keisuke, Li Junjie, Wen Xiaodong, Ou Weijun, Anwar Arnida, Chaudhary Jaideep, Takahashi Masaya, Sherry A Dean, Corbin Ian R
Advanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Hepat Oncol. 2024 Dec 31;11(1):2389031. doi: 10.1080/20450923.2024.2389031. Epub 2024 Sep 12.
The aim of this study was to assess the utility of weighted amide proton transfer (APT) MRI in three different rodent models of hepatocellular carcinoma (HCC). APT MRI was evaluated in models of diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft and human HepG2 ectopic xenograft. All models of HCC showed a higher APT signal over the surrounding normal tissues. In the DEN model, the APT signal could differentiate HCC lesions from benign nodules. Intra-arterial administration of low-density lipoprotein docosahexaenoic acid (LDL-DHA) nanoparticles to N1S1 xenografts rapidly lowered the tumor APT signal within 72 h. Direct injections of LDL-DHA nanoparticles into HepG2 xenografts also showed similar therapeutic responses. We have demonstrated the utility of APT imaging in the diagnostic/therapeutic management of HCC.
本研究的目的是评估加权酰胺质子转移（APT）磁共振成像（MRI）在三种不同的肝细胞癌（HCC）啮齿动物模型中的效用。在二乙基亚硝胺（DEN）诱导的HCC模型、N1S1同基因原位异种移植模型和人HepG2异位异种移植模型中对APT MRI进行了评估。所有HCC模型在周围正常组织上均显示出较高的APT信号。在DEN模型中，APT信号可将HCC病变与良性结节区分开来。向N1S1异种移植瘤动脉内注射低密度脂蛋白二十二碳六烯酸（LDL-DHA）纳米颗粒可在72小时内迅速降低肿瘤的APT信号。将LDL-DHA纳米颗粒直接注射到HepG2异种移植瘤中也显示出类似的治疗反应。我们已经证明了APT成像在HCC诊断/治疗管理中的效用。
