基于质谱的蛋白质组学用于系统表征工程纳米材料对生物响应
Mass spectrometry-based proteomics for system-level characterization of biological responses to engineered nanomaterials.
机构信息
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.
出版信息
Anal Bioanal Chem. 2018 Sep;410(24):6067-6077. doi: 10.1007/s00216-018-1168-6. Epub 2018 Jun 8.
Abstract
The widespread use of engineered nanomaterials or nanotechnology makes the characterization of biological responses to nanomaterials an important area of research. The application of omics approaches, such as mass spectrometry-based proteomics, has revealed new insights into the cellular responses of exposure to nanomaterials, including how nanomaterials interact and alter cellular pathways. In addition, exposure to engineered nanomaterials often leads to the generation of reactive oxygen species and cellular oxidative stress, which implicates a redox-dependent regulation of cellular responses under such conditions. In this review, we discuss quantitative proteomics-based approaches, with an emphasis on redox proteomics, as a tool for system-level characterization of the biological responses induced by engineered nanomaterials. Graphical abstract ᅟ.
摘要
广泛使用的工程纳米材料或纳米技术使得对纳米材料的生物反应进行特征描述成为一个重要的研究领域。组学方法的应用，如基于质谱的蛋白质组学，揭示了纳米材料暴露的细胞反应的新见解，包括纳米材料如何相互作用和改变细胞途径。此外，暴露于工程纳米材料通常会导致活性氧物种和细胞氧化应激的产生，这意味着在这种情况下，细胞反应受到氧化还原依赖性调节。在这篇综述中，我们讨论了基于定量蛋白质组学的方法，重点是氧化还原蛋白质组学，作为系统水平描述工程纳米材料诱导的生物反应的工具。
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