All authors are affiliated with the Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Dermatol Surg. 2020 Dec;46(12):1671-1675. doi: 10.1097/DSS.0000000000002486.
Whether picosecond lasers outperform Q-switched lasers in treating pigmented lesions has not been clearly evaluated.
To compare the efficacy and safety of picosecond and Q-switched lasers in treating epidermal and dermal pigmented lesions in Asians.
Eight subjects with lentigines and 6 subjects with acquired bilateral nevus of Ota-like macules were enrolled. Subjects was randomly treated with a picosecond laser on one side of the face and a Q-switched laser on the other side. Subjective assessments on pigment clearance, and adverse effect were obtained at Weeks 0, 4, 12, and 24 after the final treatment.
Clinical improvement differed between the 2 laser systems at Week 4 (p = .034), Week 12 (p = .039), and Week 24 (p = .027), with 85.7% of picosecond and 57.2% of Q-switched laser sites showing >50% improvement at 6 months. There was no significant difference in the incidence of side effect and healing time, but picosecond laser was significantly associated with a lower treatment discomfort (p = .05).
The picosecond laser seems to be more effective and better tolerated than Q-switched laser for the treatment of pigmented lesions in Asians.
皮秒激光是否优于调 Q 激光治疗色素性病变尚未得到明确评估。
比较皮秒和调 Q 激光治疗亚洲人表皮和真皮色素性病变的疗效和安全性。
纳入 8 例雀斑患者和 6 例获得性双侧太田痣样斑患者。将患者随机分为两组，一侧面部接受皮秒激光治疗，另一侧接受调 Q 激光治疗。在末次治疗后 0、4、12 和 24 周，对色素清除和不良反应进行主观评估。
两种激光系统在第 4 周（p =.034）、第 12 周（p =.039）和第 24 周（p =.027）的临床改善程度存在差异，皮秒激光的 85.7%和调 Q 激光的 57.2%的治疗部位在 6 个月时>50%改善。不良反应发生率和愈合时间无显著差异，但皮秒激光与较低的治疗不适相关（p =.05）。
皮秒激光治疗亚洲人的色素性病变似乎比调 Q 激光更有效且耐受性更好。
