Huang Li, Guo Hongwei
Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518120, China.
Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China.
Adv Biotechnol (Singap). 2024 Jun 7;2(2):19. doi: 10.1007/s44307-024-00027-7.
Macroautophagy, commonly referred to as autophagy, is an evolutionarily conserved cellular process that plays a crucial role in maintaining cellular homeostasis. It orchestrates the delivery of dysfunctional or surplus cellular materials to the vacuole or lysosome for degradation and recycling, particularly during adverse conditions. Over the past few decades, research has unveiled intricate regulatory mechanisms governing autophagy through various post-translational modifications (PTMs). Among these PTMs, acetylation modification has emerged as a focal point in yeast and animal studies. It plays a pivotal role in autophagy by directly targeting core components within the central machinery of autophagy, including autophagy initiation, nucleation, phagophore expansion, and autophagosome maturation. Additionally, acetylation modulates autophagy at the transcriptional level by modifying histones and transcription factors. Despite its well-established significance in yeast and mammals, the role of acetylation in plant autophagy remains largely unexplored, and the precise regulatory mechanisms remain enigmatic. In this comprehensive review, we summarize the current understanding of the function and underlying mechanisms of acetylation in regulating autophagy across yeast, mammals, and plants. We particularly highlight recent advances in deciphering the impact of acetylation on plant autophagy. These insights not only provide valuable guidance but also inspire further scientific inquiries into the intricate role of acetylation in plant autophagy.
巨自噬，通常简称为自噬，是一种在进化上保守的细胞过程，在维持细胞内稳态中起着至关重要的作用。它协调将功能失调或多余的细胞物质运输到液泡或溶酶体进行降解和再循环，特别是在不利条件下。在过去几十年中，研究通过各种翻译后修饰（PTM）揭示了控制自噬的复杂调控机制。在这些PTM中，乙酰化修饰已成为酵母和动物研究的焦点。它通过直接靶向自噬核心机制中的核心成分，包括自噬起始、成核、吞噬泡扩展和自噬体成熟，在自噬中发挥关键作用。此外，乙酰化通过修饰组蛋白和转录因子在转录水平上调节自噬。尽管乙酰化在酵母和哺乳动物中具有公认的重要性，但其在植物自噬中的作用在很大程度上仍未被探索，确切的调控机制仍然不明。在这篇全面的综述中，我们总结了目前对乙酰化在酵母、哺乳动物和植物中调节自噬的功能和潜在机制的理解。我们特别强调了在破译乙酰化对植物自噬影响方面的最新进展。这些见解不仅提供了有价值的指导，还激发了对乙酰化在植物自噬中复杂作用的进一步科学探究。
