Berlin A, Alessio L, Sesana G, Dell'Orto A, Ghezzi I
Int Arch Occup Environ Health. 1985;55(2):107-11. doi: 10.1007/BF00378372.
A previous study concluded that there are some doubts as to the validity of creatinine as a parameter for adjusting the values of biological indicators determined on spot samples of urine, since it is subject to marked inter- and intraindividual variations. Furthermore, since there was only a moderate correlation between creatinine levels and specific density, it can be assumed that these two parameters cannot be used indifferently for adjustment. Nevertheless, it seemed advisable to verify whether correction of cadmium values determined from spot samples offers any practical advantages. For this purpose, 105 subjects with occupational exposure to cadmium were examined. They collected their 24-h urine and spot samples separately at 8.00 h. There was a close correlation between CdU/spot samples and CdU/24 h. The correlation index was very similar both for CdU/spot values expressed in microgram/l and for values adjusted according to creatinine or 1024 specific gravity. These results show that no particular advantages are offered by adjusting CdU according to creatinine or specific gravity.
先前的一项研究得出结论，对于将肌酐作为调整尿液即时样本中所测定生物指标值的参数的有效性存在一些疑问，因为它存在显著的个体间和个体内差异。此外，由于肌酐水平与比重之间仅存在中等程度的相关性，可以假定这两个参数不能无差别地用于调整。然而，验证根据即时样本确定的镉值进行校正是否具有任何实际优势似乎是可取的。为此，对105名职业性接触镉的受试者进行了检查。他们分别在8:00收集24小时尿液和即时样本。镉尿/即时样本与镉尿/24小时之间存在密切相关性。对于以微克/升表示的镉尿/即时值以及根据肌酐或1024比重调整后的值，相关指数非常相似。这些结果表明，根据肌酐或比重调整镉尿并无特别优势。
