Alessio L, Berlin A, Dell'Orto A, Toffoletto F, Ghezzi I
Int Arch Occup Environ Health. 1985;55(2):99-106. doi: 10.1007/BF00378371.
The values of biological indicators used in biological monitoring are usually determined on spot samples of urine. In order to reduce the variations due to dilution, it is common practice to correct the values according to reference parameters, such as urinary creatinine concentration and specific gravity. The aim of the present study was to verify whether creatinine possesses the necessary characteristics for adjustment. The levels of creatinine were not influenced by diuresis, but, contrary to what was expected, the values of the metabolite showed marked intra- and interindividual variations. These data raise serious doubts as to the validity of creatinine as a parameter that can be used for adjustment purposes, and suggest that it would be advisable to ascertain for each biological indicator whether in fact adjustment is of any use. Lastly, since there was only a slight correlation between creatinine levels and specific gravity values, it is concluded that these two parameters cannot be used indifferently for adjustment.
生物监测中使用的生物指标值通常是根据尿液现场样本确定的。为了减少因稀释导致的差异，根据诸如尿肌酐浓度和比重等参考参数对数值进行校正已成为惯例。本研究的目的是验证肌酐是否具备用于校正的必要特性。肌酐水平不受利尿影响，但与预期相反，该代谢物的值在个体内和个体间存在显著差异。这些数据对肌酐作为可用于校正目的的参数的有效性提出了严重质疑，并表明对于每种生物指标，确定校正是否真的有用是可取的。最后，由于肌酐水平与比重值之间只有微弱的相关性，得出的结论是这两个参数不能随意用于校正。
