新加坡母婴间的乙肝病毒传播

Maternal-child hepatitis B virus transmission in Singapore.

作者信息

Chan S H, Tan K L, Goh K T, Lim C, Tsakok M, Oon C J, Ratnam S S

出版信息

Int J Epidemiol. 1985 Mar;14(1):173-7. doi: 10.1093/ije/14.1.173.

DOI:10.1093/ije/14.1.173

Abstract

A study of maternal-infant transmission of hepatitis B virus (HBV) was conducted in Singapore between June 1980 and June 1982. HBsAg carrier rate was highest among Chinese (6.2%) followed by Malay (2.3%) and Indian (0.6%) mothers. The presence of HBeAg in maternal sera correlated well with high titre HBsAg (p = 7.34 X 10(-5)). Overall HBV transmission occurred in 27/56 (48.2%) infants from carrier mothers. The majority of the transmission was perinatal. There was a very strong correlation between transmission and HBeAg status of the mother (p = 1.85 X 10(-9); odds ratio = 68.44) and to a lesser extent with high titre HBsAg (p = 0.002; odds ratio = 6.38). A strong negative correlation was seen between transmission and anti-HBeAg (p = 8.19 X 10(-7); odds ratio = 0.04). At one year 19 (70.4%) infants were still HBsAg positive while seven (25.9%) lost the antigenemia and acquired anti-HBsAg and one developed HBsAg after one year. It could be calculated that perinatal HBV transmission contributed about 18% to the total pool of HBsAg positive infants of one year of age.

摘要

1980年6月至1982年6月期间，在新加坡开展了一项关于乙型肝炎病毒（HBV）母婴传播的研究。乙肝表面抗原（HBsAg）携带率在中国母亲中最高（6.2%），其次是马来母亲（2.3%）和印度母亲（0.6%）。母亲血清中乙肝e抗原（HBeAg）的存在与高滴度HBsAg密切相关（p = 7.34×10⁻⁵）。总体而言，56名携带HBsAg母亲的婴儿中有27名（48.2%）发生了HBV传播。大多数传播发生在围产期。传播与母亲的HBeAg状态之间存在非常强的相关性（p = 1.85×10⁻⁹；优势比 = 68.44），在较小程度上与高滴度HBsAg也有关（p = 0.002；优势比 = 6.38）。传播与抗HBeAg之间存在强烈的负相关（p = 8.19×10⁻⁷；优势比 = 0.04）。一岁时，19名（70.4%）婴儿仍为HBsAg阳性，7名（25.9%）清除了抗原血症并获得了抗HBsAg，1名在一岁后出现了HBsAg。据计算，围产期HBV传播对一岁HBsAg阳性婴儿总数的贡献约为18%。