Longmaid H E, Adams D F, Neirinckx R D, Harrison C G, Brunner P, Seltzer S E, Davis M A, Neuringer L, Geyer R P
Invest Radiol. 1985 Mar-Apr;20(2):141-5. doi: 10.1097/00004424-198503000-00009.
In vivo magnetic resonance imaging (MRI) has employed almost exclusively the proton because of its high gyromagnetic ratio and natural abundance relative to other nuclei. Recent research has focused on imaging using nuclei other than 1H, but has been limited by the decreased sensitivity and/or low biologic concentrations of the nuclei. Fluorine (19F), with a gyromagnetic ratio second only to that of hydrogen, is a theoretically attractive nucleus for MRI, but fluorine is present in only minute amounts in most tissues. Perfluorochemical emulsions (PFC), developed as blood replacement agents, appear to be safe vehicles for fluorine administration. We report our initial results of in vivo 19F magnetic resonance imaging of liver, tumor, and abscess in rats given exogenous fluorine.
由于质子相对于其他原子核具有较高的旋磁比和天然丰度，体内磁共振成像（MRI）几乎一直仅使用质子。最近的研究集中在使用除氢（¹H）以外的原子核进行成像，但受到这些原子核灵敏度降低和/或生物浓度低的限制。氟（¹⁹F）的旋磁比仅次于氢，从理论上讲是MRI的理想原子核，但氟在大多数组织中仅以微量存在。作为血液替代品开发的全氟化学乳剂（PFC）似乎是安全的氟给药载体。我们报告了给大鼠外源性氟后，对其肝脏、肿瘤和脓肿进行体内¹⁹F磁共振成像的初步结果。
