Liu Beiqin, Wang Shuyue, Ma Hong, Deng Yulin, Du Jichen, Zhao Yimeng, Chen Yu
Aerospace Medical Center, Aerospace Center Hospital, Beijing, China.
School of Medical Technology, Beijing Institute of Technology, Beijing, China.
J Transl Med. 2025 Jan 30;23(1):132. doi: 10.1186/s12967-024-05986-y.
Heart-on-a-chip (HoC) devices have emerged as a powerful tool for studying the human heart's intricate functions and dysfunctions in vitro. Traditional preclinical models, such as 2D cell cultures model and animal model, have limitations in accurately predicting human response to cardiovascular diseases and treatments. The HoC approach addresses these shortcomings by recapitulating the microscale anatomy, physiology, and biomechanics of the heart, thereby providing a more clinically relevant platform for drug testing, disease modeling, and personalized therapy. Recent years have seen significant strides in HoC technology, driven by advancements in biomaterials, bioelectronics, and tissue engineering. Here, we first review the construction and on-chip detection in HoC. Then we introduce the current proceedings of in vitro models for studying cardiovascular diseases (CVD) based on the HoC platform, including ischemia and myocardial infarction, cardiac fibrosis, cardiac scar, myocardial hypertrophy and other CVD models. Finally, we discuss the future directions of HoC and related emerging technologies.
芯片上的心脏（HoC）装置已成为一种强大的工具，用于在体外研究人类心脏的复杂功能和功能障碍。传统的临床前模型，如二维细胞培养模型和动物模型，在准确预测人类对心血管疾病和治疗的反应方面存在局限性。HoC方法通过概括心脏的微观解剖结构、生理学和生物力学来解决这些缺点，从而为药物测试、疾病建模和个性化治疗提供一个更具临床相关性的平台。近年来，在生物材料、生物电子学和组织工程的推动下，HoC技术取得了重大进展。在这里，我们首先回顾HoC的构建和芯片上的检测。然后我们介绍基于HoC平台研究心血管疾病（CVD）的体外模型的当前进展，包括缺血和心肌梗死、心脏纤维化、心脏瘢痕、心肌肥大和其他CVD模型。最后，我们讨论HoC和相关新兴技术的未来方向。
