用于疾病建模、药物开发和个性化治疗的心血管人体芯片器官平台。
Cardiovascular human organ-on-a-chip platform for disease modeling, drug development, and personalized therapy.
作者信息
Khanna Astha, Oropeza Beu P, Huang Ngan F
机构信息
Graver Technologies, Newark, New Jersey, USA.
Department of Cardiothoracic Surgery, Stanford University, Stanford, California, USA.
出版信息
J Biomed Mater Res A. 2024 Apr;112(4):512-523. doi: 10.1002/jbm.a.37602. Epub 2023 Sep 5.
Abstract
Cardiovascular organ-on-a-chip (OoC) devices are composed of engineered or native functional tissues that are cultured under controlled microenvironments inside microchips. These systems employ microfabrication and tissue engineering techniques to recapitulate human physiology. This review focuses on human OoC systems to model cardiovascular diseases, to perform drug screening, and to advance personalized medicine. We also address the challenges in the generation of organ chips that can revolutionize the large-scale application of these systems for drug development and personalized therapy.
摘要
心血管器官芯片（OoC）装置由在微芯片内可控微环境下培养的工程化或天然功能组织组成。这些系统采用微制造和组织工程技术来重现人体生理学。本综述聚焦于用于模拟心血管疾病、进行药物筛选以及推动个性化医疗的人体OoC系统。我们还探讨了在生成能够彻底改变这些系统在药物开发和个性化治疗方面大规模应用的器官芯片时所面临的挑战。
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