Wang Jing, Ma Lan, Fang Yu, Ye Tengteng, Li Hongbo, Lan Peng
Department of Cardiology, Nanning Hospital of Traditional Chinese Medicine, Nanning, Guangxi, China.
Department of Neurology, Wenzhou Traditional Chinese Medicine (TCM) Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang, China.
Front Immunol. 2025 Jan 16;15:1490395. doi: 10.3389/fimmu.2024.1490395. eCollection 2024.
The glycocalyx is a layer of villus-like structure covering the luminal surface of vascular endothelial cells. Damage to the glycocalyx has been proven linked to the development of many diseases. However, the factors that promote damage to the glycocalyx are not fully elaborated. This review summarizes factors leading to the reduction of the glycocalyx in detail, including inflammatory factors, ischemia-reperfusion, oxidative stress, lipids, glucose, high sodium, female sex hormones and others. Additionally, the mechanisms underlying its degradation are discussed. To better prevent and treat related diseases induced by glycocalyx degradation, it is a meaningful measure to avoid these factors.
糖萼是一层覆盖血管内皮细胞腔面的绒毛状结构。已证实糖萼损伤与多种疾病的发生有关。然而，促进糖萼损伤的因素尚未完全阐明。本综述详细总结了导致糖萼减少的因素，包括炎症因子、缺血再灌注、氧化应激、脂质、葡萄糖、高钠、女性性激素等。此外，还讨论了其降解的机制。为了更好地预防和治疗由糖萼降解引起的相关疾病，避免这些因素是一项有意义的措施。
