关节腔内注射透明质酸和富血小板血浆在治疗膝关节骨关节炎关节疼痛中的作用
The Role of Intraarticular Injections of Hyaluronic Acid and Platelet Rich Plasma for the Treatment of Articular Pain in Knee Osteoarthritis.
作者信息
Rodriguez-Merchan E Carlos, De la Corte-Rodriguez Hortensia
机构信息
Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain.
Department of Physical Medicine and Rehabilitation, La Paz University Hospital-IdiPaz, Madrid, Spain.
出版信息
Arch Bone Jt Surg. 2025;13(1):54-61. doi: 10.22038/ABJS.2024.78852.3621.
Abstract
The purpose of this in brief article was to determine the current role of intraarticular injections of hyaluronic acid (HA) and platelet-rich plasma (PRP) for the treatment of painful KOA. It has been reported that the average duration of effectiveness (pain relief) of one injection of extended-release HA is around one year. Kellgren-Lawrence grade (I-II versus III-IV), male gender, and older age are associated with a longer duration of effectiveness. Cartilage degeneration might be improved with a higher number of injections of HA. Intraarticular injections of HA alleviate pain, function, and diminish non-steroidal anti-inflammatory drugs (NSAIDs) consumption. In addition, several studies have indicated that the combination of HA and PRP is more effective than HA alone. Finally, other studies seemed to demonstrate that PRP was more effective than HA.
摘要
这篇简短文章的目的是确定关节内注射透明质酸（HA）和富血小板血浆（PRP）在治疗疼痛性膝骨关节炎（KOA）中的当前作用。据报道，单次注射缓释HA的平均有效持续时间（疼痛缓解）约为一年。凯尔格伦-劳伦斯分级（I-II级与III-IV级）、男性性别和年龄较大与较长的有效持续时间相关。增加HA注射次数可能改善软骨退变。关节内注射HA可减轻疼痛、改善功能并减少非甾体抗炎药（NSAIDs）的使用。此外，多项研究表明，HA与PRP联合使用比单独使用HA更有效。最后，其他研究似乎表明PRP比HA更有效。
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本文引用的文献
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Knee osteoarthritis: disease burden, available treatments, and emerging options.膝骨关节炎：疾病负担、现有治疗方法及新出现的选择
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Platelet-rich plasma injections for the management of knee osteoarthritis: The ESSKA-ICRS consensus. Recommendations using the RAND/UCLA appropriateness method for different clinical scenarios.富血小板血浆注射治疗膝关节骨关节炎：ESSKA-ICRS 共识。使用 RAND/UCLA 适宜性方法为不同临床情况推荐的建议。
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The burden of knee osteoarthritis worldwide, regionally, and nationally from 1990 to 2019, along with an analysis of cross-national inequalities.全球、地区和国家层面 1990 年至 2019 年的膝关节骨关节炎负担，以及对国家间不平等的分析。
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