Rouveix B, Derouin F, Levacher M
J Clin Microbiol. 1985 Apr;21(4):649-51. doi: 10.1128/jcm.21.4.649-651.1985.
Cellular immune response was evaluated in 31 patients with chronic Schistosoma haematobium and Schistosoma mansoni infections and in 15 healthy normal persons by using S. mansoni soluble worm and egg antigens. Although the leukocyte migration inhibition test demonstrated false-positive reactions, the specificity of the leukocyte aggregation test was confirmed by the negativity of all of the controls. Among the patients, only 10% were positive for the leukocyte aggregation test. This low cellular reactivity was in contrast to markedly elevated specific humoral response determined by an enzyme-linked immunosorbent assay for immunoglobulin G and paper allergosorbent test for immunoglobulin E with soluble worm antigen. These results confirm that the cellular immune reactivity to schistosome antigen as demonstrated by the leukocyte aggregation test is either minimal or absent in chronically infected patients.
通过使用曼氏血吸虫可溶性虫体和虫卵抗原，对31例慢性埃及血吸虫和曼氏血吸虫感染患者及15名健康正常人的细胞免疫反应进行了评估。虽然白细胞迁移抑制试验显示出假阳性反应，但所有对照均为阴性，证实了白细胞聚集试验的特异性。在患者中，只有10%的白细胞聚集试验呈阳性。这种低细胞反应性与用可溶性虫体抗原通过酶联免疫吸附测定免疫球蛋白G和纸过敏吸附试验测定免疫球蛋白E所确定的明显升高的特异性体液反应形成对比。这些结果证实，在慢性感染患者中，白细胞聚集试验所显示的对血吸虫抗原的细胞免疫反应要么极小，要么不存在。
