流感疫苗对老年人茶碱水平及华法林抗凝作用无影响。

Lack of effect of influenza vaccine on theophylline levels and warfarin anticoagulation in the elderly.

作者信息

Gomolin I H, Chapron D J, Luhan P A

出版信息

J Am Geriatr Soc. 1985 Apr;33(4):269-72. doi: 10.1111/j.1532-5415.1985.tb07115.x.

DOI:10.1111/j.1532-5415.1985.tb07115.x

Abstract

Steady state theophylline concentrations were prospectively measured in 13 elderly institutionalized individuals following influenza vaccination. Vaccine-mediated increase in concentrations could not be identified. In seven individuals receiving warfarin, no change in prothrombin or partial thromboplastin times occurred following vaccination. No adverse drug reactions were observed. The following year 14 individuals receiving theophylline and 12 receiving warfarin were vaccinated without adverse drug reactions noticed. These data fail to support previous reports of influenza vaccine inhibition of theophylline metabolism or vaccine-enhanced anticoagulation and are consistent with recent reports on younger subjects.

摘要

前瞻性地测量了13名老年机构化个体接种流感疫苗后的稳态茶碱浓度。未发现疫苗介导的浓度升高。在7名接受华法林治疗的个体中，接种疫苗后凝血酶原时间或部分凝血活酶时间没有变化。未观察到药物不良反应。次年，14名接受茶碱治疗的个体和12名接受华法林治疗的个体接种了疫苗，未发现药物不良反应。这些数据不支持先前关于流感疫苗抑制茶碱代谢或疫苗增强抗凝作用的报道，与最近关于年轻受试者的报道一致。