Nielsen Marisa C, Miller Nancy S
Clinical Microbiology, Department of Pathology and Laboratory Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine.
Clinical Microbiology, Department of Pathology and Laboratory Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine.
Clin Lab Med. 2025 Mar;45(1):137-144. doi: 10.1016/j.cll.2024.10.008. Epub 2024 Dec 12.
Lyme disease, also referred to as Lyme borreliosis (LB), is an infection caused by tick-borne spirochetes in the Borrelia burgdorferi sensu lato (s.l) complex and is the most common vector-borne disease in the United States. Nonspecific clinical manifestations, pathogen persistence, immune system evasion, species-dependent tropism, and inherent limitations of current diagnostic assays, have all contributed to the diagnostic challenges associated with LB. This review presents a succinct summary of LB epidemiology, current recommended testing strategies, available technologies, and the future directions of LB diagnostics in the United States.
莱姆病，也称为莱姆疏螺旋体病（LB），是一种由蜱传播的伯氏疏螺旋体狭义复合体中的螺旋体引起的感染，是美国最常见的媒介传播疾病。非特异性临床表现、病原体持续存在、免疫系统逃避、物种依赖性嗜性以及当前诊断检测方法的固有局限性，都导致了与莱姆病相关的诊断挑战。本综述简要总结了美国莱姆病的流行病学、当前推荐的检测策略、可用技术以及莱姆病诊断的未来方向。
