Cai Shuqing, Rehmat Noreen, Mahmood Zafar, Chen Qian, Huo Yanping, Ji Shaomin
School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, P. R. China.
Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center, Jieyang 515200, P. R. China.
ACS Omega. 2025 Jan 13;10(3):2421-2427. doi: 10.1021/acsomega.4c02844. eCollection 2025 Jan 28.
Phenols are of particular importance owing to their widespread application in various fields, including life sciences and synthetic chemistry. However, the typical synthetic strategies of phenol either rely on metal- or photo-catalysts or involve stringent conditions such as high temperature, strong oxidants, and acidic or basic environments. Herein, we present a remarkably simple, ecofriendly, and photocatalyst-free synthesis of phenols. In contrast to conventional methods, which relies on expensive catalysts or hazardous reagents, the current diacetoxyiodobenzene-mediated hydroxylation of arylboronic acid protocol offers significant improvement in terms of costs, operational simplicity, toxicity, and sustainability. The reaction does not require high temperature or light activation and shows good functional group compatibility and conversion efficiency (55-96%). Moreover, these mild reaction conditions are also useful for gram-scale synthesis without compromising the reaction yield.
由于酚类化合物在包括生命科学和合成化学在内的各个领域都有广泛应用，因此具有特别重要的意义。然而，酚类化合物的典型合成策略要么依赖金属催化剂或光催化剂，要么涉及高温、强氧化剂以及酸性或碱性环境等苛刻条件。在此，我们展示了一种极其简单、环保且无光催化剂的酚类化合物合成方法。与依赖昂贵催化剂或危险试剂的传统方法不同，当前通过二乙酰氧基碘苯介导的芳基硼酸羟基化方案在成本、操作简便性、毒性和可持续性方面有显著改进。该反应不需要高温或光活化，并且具有良好的官能团兼容性和转化效率（55 - 96%）。此外，这些温和的反应条件对于克级规模的合成也很有用，且不会降低反应产率。
