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-治疗黄褐斑的有效成分及其实验研究

Effective Components of - in the Treatment of Melasma and Its Experimental Study.

作者信息

Wei Yunxia, Yu Xufeng, Zhao Jing, Gao Mingzhou, Qiao Mingqi

机构信息

Shandong University of Traditional Chinese Medicine, Jinan 250355, China.

Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.

出版信息

ACS Omega. 2025 Jan 14;10(3):3033-3043. doi: 10.1021/acsomega.4c09799. eCollection 2025 Jan 28.

DOI:10.1021/acsomega.4c09799
PMID:39895736
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11780428/
Abstract

PURPOSE

The main purpose of this study was to predict and verify the active ingredients of - in melasma based on network pharmacology analysis and experimental verification.

MATERIALS AND METHODS

  • was investigated by network pharmacology, GEO database analysis, and molecular docking techniques to screen its active ingredients. The active components of - were further validated by an in vitro α-melanin-induced B16F10 melanoma cell model and an in vivo UV irradiation combined with a progesterone injection-induced melasma rat model.

RESULTS

Network pharmacology analysis and molecular docking showed that salvianolic acid B might be the key active ingredient. In vitro cellular experiments revealed that salvianolic acid B inhibits tyrosinase activity in B16F10 cells at concentrations of 60-90 nmol/mL. In vivo animal experiments found that TYR, MDA, and TNF-α were decreased in the skin and serum of rats in the group of the low-, medium-, and high-dose groups of salvianolic acid B, and the expression of GSH-Px and SOD was increased. The high-dose groups of salvianolic acid B showed the best therapeutic effect.

CONCLUSION

In this study, experiments collectively show that salvianolic acid B in - slows down the process of melasma by inhibiting lipid peroxidation in the organism, increasing the antioxidant capacity of the skin, decreasing the activity of tyrosinase, and providing anti-inflammation. This highlights the successful application of network pharmacology and provides a scientific basis for the clinical citation of - in treating melasma.

摘要

目的

本研究的主要目的是基于网络药理学分析和实验验证来预测和验证[具体药物名称未给出]治疗黄褐斑的活性成分。

材料与方法

通过网络药理学、基因表达综合数据库（GEO）分析及分子对接技术对[具体药物名称未给出]进行研究，以筛选其活性成分。[具体药物名称未给出]的活性成分通过体外α - 黑色素诱导的B16F10黑色素瘤细胞模型和体内紫外线照射联合黄体酮注射诱导的黄褐斑大鼠模型进一步验证。

结果

网络药理学分析和分子对接表明，丹酚酸B可能是关键活性成分。体外细胞实验显示，丹酚酸B在60 - 90 nmol/mL浓度下可抑制B16F10细胞中的酪氨酸酶活性。体内动物实验发现，丹酚酸B低、中、高剂量组大鼠皮肤和血清中的酪氨酸酶（TYR）、丙二醛（MDA）和肿瘤坏死因子 - α（TNF - α）水平降低，谷胱甘肽过氧化物酶（GSH - Px）和超氧化物歧化酶（SOD）的表达增加。丹酚酸B高剂量组显示出最佳治疗效果。

结论

在本研究中，实验共同表明，[具体药物名称未给出]中的丹酚酸B通过抑制机体脂质过氧化、提高皮肤抗氧化能力、降低酪氨酸酶活性及发挥抗炎作用来减缓黄褐斑进程。这突出了网络药理学的成功应用，并为[具体药物名称未给出]治疗黄褐斑的临床引用提供了科学依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/3f6c03b583b9/ao4c09799_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/6c875afee6d3/ao4c09799_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/b8c3edf1094f/ao4c09799_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/e4e9903c3d3e/ao4c09799_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/6af974854ea2/ao4c09799_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/a01032e656a4/ao4c09799_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/7a3ac381dbef/ao4c09799_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/eb3ae1efd259/ao4c09799_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/0bbba88e6f22/ao4c09799_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/808c3dada8fd/ao4c09799_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/3f6c03b583b9/ao4c09799_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/6c875afee6d3/ao4c09799_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/b8c3edf1094f/ao4c09799_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/e4e9903c3d3e/ao4c09799_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/6af974854ea2/ao4c09799_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/a01032e656a4/ao4c09799_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/7a3ac381dbef/ao4c09799_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/eb3ae1efd259/ao4c09799_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/0bbba88e6f22/ao4c09799_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/808c3dada8fd/ao4c09799_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1e8/11780428/3f6c03b583b9/ao4c09799_0010.jpg

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The signaling pathways of traditional Chinese medicine in treating diabetic retinopathy.中药治疗糖尿病视网膜病变的信号通路
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Panax notoginseng saponins normalises tumour blood vessels by inhibiting EphA2 gene expression to modulate the tumour microenvironment of breast cancer.
三七总皂苷通过抑制 EphA2 基因表达使肿瘤血管正常化，从而调节乳腺癌的肿瘤微环境。
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