Wang Z W, Gao S Z, Cheng B C
Department of Thoracic and Cardiovascular Surgery, First Affiliated Hospital, Hubei Medical University, Wuhan.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 May;17(5):292-4.
To explore the therapeutic mechanism of Salvia miltiorrhize, ligustrazine and Panax notoginseng in treating late hemorrhagic shock in rabbit.
Rabbit hemorrhagic shock models (MPA 5.3 kPa) were set up according to Wiggers' method and administrated Salvia miltiorrhiza, ligustrazine, Panax notoginseng. The values of blood RBC superoxide dismutase (SOD) and blood lactate (BL), plasma malondialdehyde (MDA) and magnesium (Mg++) were continuously monitored before shock, 120 minutes after shock, 60 and 120 minutes after hydraulic dilatation.
(1) In 120 minutes after shock, the level of SOD decreased and the concentrations of MDA, BL, Mg++ were markedly increased, which indicated that the cell membrane damage caused by oxygen free radicals in rabbit hemorrhagic shock. (2) Salvia miltiorrhiza, Ligustrazine or Panax notoginseng could alleviate lipidperoxidation injury to tissue. Compared with the single drug administration groups, the effects of oxygen free radicals scavangers by combined administration with half dose of 2 drugs were better than the single drug with full dose alone and the side effects such as depression of blood pressure and heart rates would be alleviated.
Combined administration of Salvia miltiorrhiza, ligustrazine and Panax notoginseng would half the dosage, the blood pressure depression and heart rate reduction alleviated and better result obtained.
探讨丹参、川芎嗪及三七治疗家兔晚期失血性休克的作用机制。
采用Wiggers法建立家兔失血性休克模型（平均动脉压5.3 kPa），并给予丹参、川芎嗪、三七。在休克前、休克后120分钟、补液后60和120分钟连续监测血红细胞超氧化物歧化酶（SOD）值、血乳酸（BL）、血浆丙二醛（MDA）和镁（Mg++）。
（1）休克后120分钟，SOD水平降低，MDA、BL、Mg++浓度显著升高，提示家兔失血性休克时氧自由基导致细胞膜损伤。（2）丹参、川芎嗪或三七可减轻组织脂质过氧化损伤。与单药给药组相比，两药半量联合给药清除氧自由基的效果优于单药全量，且可减轻血压和心率下降等副作用。
丹参、川芎嗪及三七联合应用可减半用药剂量，减轻血压下降和心率减慢，效果更佳。
