Kener Daisy, Childress Darrell, Andrus Ian, Olson Jared, Webb Brandon
Department of Pharmacy, Intermountain Health Utah-St George Regional Hospital, St George, Utah, USA.
Department of Pharmacy, Intermountain Health Utah-Primary Children's Hospital, Salt Lake City, Utah, USA.
Open Forum Infect Dis. 2025 Jan 17;12(2):ofaf012. doi: 10.1093/ofid/ofaf012. eCollection 2025 Feb.
Multiple observational studies in methicillin-resistant and enterococcal infections have suggested that higher doses of daptomycin may be associated with better clinical outcomes. However, optimal daptomycin dosing in methicillin-sensitive bloodstream infections remains unclear. In this multicentered, retrospective, observational cohort study, we compared standard dose daptomycin (<8 mg/kg) vs high dose (≥8 mg/kg) for methicillin-sensitive bloodstream infections. In a propensity-weighted model, the composite outcome of treatment failure within 90 days was lower in the high-dose group relative to the standard dose group (odds ratio, 0.496; 95% CI, .306-.804). We did not detect any significant difference in safety outcomes.
多项针对耐甲氧西林和肠球菌感染的观察性研究表明，较高剂量的达托霉素可能与更好的临床结果相关。然而，对于甲氧西林敏感的血流感染，达托霉素的最佳剂量仍不清楚。在这项多中心、回顾性、观察性队列研究中，我们比较了甲氧西林敏感血流感染患者使用标准剂量（<8mg/kg）与高剂量（≥8mg/kg）达托霉素的情况。在倾向加权模型中，高剂量组90天内治疗失败的复合结局低于标准剂量组（优势比，0.496；95%CI，0.306 - 0.804）。我们未发现安全结局有任何显著差异。
