熊果酸及其潜在生物学应用的最新进展。

Recent developments on ursolic acid and its potential biological applications.

作者信息

Arulnangai R, Asia Thabassoom H, Vajiha Banu H, Thirugnanasambandham K, Ganesamoorthy R

机构信息

PG & Research Department of Chemistry, Jamal Mohamed College, Trichy, Tamil Nadu, India.

PG and Research Department of Microbiology, Jamal Mohamed College, Trichy, Tamil Nadu, India.

出版信息

Toxicol Rep. 2025 Jan 10;14:101900. doi: 10.1016/j.toxrep.2025.101900. eCollection 2025 Jun.

DOI:10.1016/j.toxrep.2025.101900

PMID:39897400

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11786699/

Abstract

A naturally occurring pentacyclic triterpenoid, ursolic acid (UA) has attracted a lot of interest due to its various pharmacological characteristics and its medical uses. The goal of this thorough review is to present a thorough examination of the therapeutic benefits of UA, including its anti-inflammatory, antioxidant, anticancer, antibacterial, and metabolic-regulating properties. We go over its origins, pharmacological characteristics, and advantages in the treatment of several illnesses, including cancer, neurological disorders, metabolic disorders, and cardiovascular diseases. We further emphasize its potential to improve exercise capacity and its growing function as an exercise mimic. UA's therapeutic potential is thoroughly explained in this review, which highlights the compound's potential as a natural remedy for several illnesses.

摘要

熊果酸（UA）是一种天然存在的五环三萜类化合物，因其具有多种药理特性和医学用途而备受关注。本全面综述的目的是对UA的治疗益处进行全面考察，包括其抗炎、抗氧化、抗癌、抗菌和代谢调节特性。我们探讨了它的来源、药理特性以及在治疗多种疾病（包括癌症、神经疾病、代谢紊乱和心血管疾病）方面的优势。我们还进一步强调了它改善运动能力的潜力以及作为运动模拟物的日益重要的作用。本综述全面阐述了UA的治疗潜力，突出了该化合物作为多种疾病天然疗法的潜力。