Cosentino M J, Nishida M, Rabinowitz R, Cockett A T
J Urol. 1985 May;133(5):906-11. doi: 10.1016/s0022-5347(17)49278-0.
Prepubertal rats were exposed to unilateral spermatic cord torsion for 0, 1, 3, 5, 9 or 12 hours duration. At the end of this time the damaged testes were either removed or untwisted and pexed into place. The animals were then allowed to mature to 77 days of age at which time the contralateral testes were examined for 12 histological parameters and scored according to the degree of pathology noted in each. Pathological changes in the contralateral testes were found to be dependent on the duration of spermatic cord torsion but were less severe in the orchiectomized group. Thus, removal of the damaged organ minimized the long-term damage to the contralateral testes. We also noted that specific histological parameters of the contralateral testes correlated well with fertility and that specific changes in the ipsilateral testes predicted contralateral pathology.
对青春期前大鼠进行单侧精索扭转，持续时间分别为0、1、3、5、9或12小时。在此时间段结束时，受损睾丸要么被切除，要么被解开扭转并固定到位。然后让动物成熟至77日龄，此时检查对侧睾丸的12个组织学参数，并根据每个参数中观察到的病理程度进行评分。发现对侧睾丸的病理变化取决于精索扭转的持续时间，但在睾丸切除组中较轻。因此，切除受损器官可将对对侧睾丸的长期损害降至最低。我们还注意到，对侧睾丸的特定组织学参数与生育能力密切相关，同侧睾丸的特定变化可预测对侧病理情况。
