Cosentino M J, Nishida M, Rabinowitz R, Cockett A T
J Androl. 1986 Jan-Feb;7(1):23-31. doi: 10.1002/j.1939-4640.1986.tb00862.x.
Sixty prepubertal rats were subjected to unilateral spermatic cord torsion for a duration of 0, 1, 3, 5, 9 or 12 hours. At the end of this period, the ipsilateral testes either were removed for immediate processing or subjected to detorsion and orchiopexy, followed by a six-week recovery period prior to histologic study. Twelve histologic parameters were each scored according to the degree of pathologic findings, thus allowing for a quantitative assessment of testicular damage. The sequence of specific histologic degeneration that occurred with spermatic cord torsion is described. These changes were found to be dependent on the duration of torsion, with the greatest damage occurring after three hours or more. In the animals undergoing detorsion followed by a six-week recovery period, severe degeneration was noted for all durations of torsion studied. The extent of this degeneration was significantly correlated with a reduction in fertility.
60只青春期前大鼠接受单侧精索扭转，持续时间为0、1、3、5、9或12小时。在此期间结束时，同侧睾丸要么被切除以便立即进行处理，要么进行扭转复位和睾丸固定术，然后在组织学研究前有六周的恢复期。根据病理结果的程度对12个组织学参数分别进行评分，从而对睾丸损伤进行定量评估。描述了精索扭转时发生的特定组织学变性的顺序。发现这些变化取决于扭转的持续时间，三小时或更长时间后损伤最大。在接受扭转复位并经过六周恢复期的动物中，在所研究的所有扭转持续时间内均观察到严重变性。这种变性的程度与生育力降低显著相关。
