Qu Qianyu, Dou Qingyu, Xiang Zhejun, Yu Bin, Chen Lili, Fan Zhenxin, Zhao Xing, Yang Shujuan, Zeng Peibin
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
National Clinical Research Center of Geriatrics, Geriatric Medicine Center, West China Hospital, Sichuan University, Chengdu, China.
NPJ Biofilms Microbiomes. 2025 Feb 4;11(1):24. doi: 10.1038/s41522-025-00661-6.
Gut microbiota affects host health and disease. Large-scale cohorts have explored the interactions between the microbiota, host, and environment to reveal the disease-associated microbiota variation. A population-level gut metagenomic cohort is still rare in China. Here, we performed metagenomic sequencing on fecal samples from the CMEC Microbiome Project in Southwest China. In this study, we identified host socioeconomics, diet, lifestyle, and medical measurements that were significantly associated with microbiome function and composition. We revealed extensive novel associations between the host microbiome and common metabolic disorders. Our results provide new insight into associations of gut microbiota with metabolic disorders so as to support the translation of gut microbiome findings into potential clinical practice.
肠道微生物群影响宿主健康和疾病。大规模队列研究已探索微生物群、宿主和环境之间的相互作用，以揭示与疾病相关的微生物群变异。在中国，基于人群水平的肠道宏基因组队列研究仍然很少见。在此，我们对中国西南部CMEC微生物组计划的粪便样本进行了宏基因组测序。在本研究中，我们确定了与微生物组功能和组成显著相关的宿主社会经济状况、饮食、生活方式和医学测量指标。我们揭示了宿主微生物组与常见代谢紊乱之间广泛的新关联。我们的结果为肠道微生物群与代谢紊乱之间的关联提供了新的见解，以支持将肠道微生物组研究结果转化为潜在的临床实践。
