Zhang Yingcong, Yang Yiran, Yin Zhixin, Huang Lin, Wang Jiayi
Department of Clinical Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Institute of Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
iScience. 2025 Jan 7;28(2):111763. doi: 10.1016/j.isci.2025.111763. eCollection 2025 Feb 21.
Recent years have witnessed tremendous advances in wearable sensors, which play an essential role in personalized healthcare for their ability for real-time sensing and detection of human health information. Nanozymes, capable of mimicking the functions of natural enzymes and addressing their limitations, possess unique advantages such as structural stability, low cost, and ease of mass production, making them particularly beneficial for constructing recognition units in wearable biosensors. In this review, we aim to delineate the latest advancements in nanozymes for the development of wearable biosensors, focusing on key developments in nanozyme immobilization strategies, detection technologies, and biomedical applications. The review also highlights the current challenges and future perspectives. Ultimately, it aims to provide insights for future research endeavors in this rapidly evolving area.
近年来，可穿戴传感器取得了巨大进展，因其能够实时感知和检测人体健康信息，在个性化医疗中发挥着至关重要的作用。纳米酶能够模拟天然酶的功能并克服其局限性，具有结构稳定性、低成本和易于大规模生产等独特优势，使其特别有利于构建可穿戴生物传感器中的识别单元。在本综述中，我们旨在阐述用于可穿戴生物传感器开发的纳米酶的最新进展，重点关注纳米酶固定化策略、检测技术和生物医学应用方面的关键进展。该综述还强调了当前的挑战和未来展望。最终，旨在为这一快速发展领域的未来研究工作提供见解。
