Yin Si-Yue, Liu Yu-Chen, Yang Yi-Pin, Liang Bing-Yu, Fu Zi-Yue, Fan Min, Zhang Yu-Chen, Xie Zi-Hui, Han Ke, Wang Jian-Peng, Zhang Lei, Zhang Liang, Tong Bu-Sheng, Han Yan-Xun, Zhang Cong-Jun
Department of Oncology.
Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Int J Surg. 2025 Apr 1;111(4):3129-3134. doi: 10.1097/JS9.0000000000002293.
Evidence suggests a potential link between metabolic dysfunction and head and neck cancer (HNC). This study investigates the potential causal relationships between metabolic dysfunction and HNC using genetic data. While no significant causal associations were identified between metabolic indicators and HNC risk, the research revealed that inhibition of certain genes could reduce cancer risk. Specifically, inhibiting sodium/glucose cotransporter 2 (SLC5A2) was associated with a decreased risk of HNC and oropharyngeal cancer (OPC), while ATP-sensitive inward rectifier potassium channel 11 inhibition was linked to a reduced risk of oral cavity cancer. Additionally, inhibiting SLC5A1 and voltage-dependent L-type calcium channel subunit beta-2 showed a connection to lower OPC risk. These findings suggest that targeting these genes could offer promising therapeutic strategies for preventing and treating HNC, as well as improving both preoperative and postoperative management in affected patients.
有证据表明代谢功能障碍与头颈癌（HNC）之间存在潜在联系。本研究利用基因数据调查代谢功能障碍与头颈癌之间的潜在因果关系。虽然未发现代谢指标与头颈癌风险之间存在显著的因果关联，但研究表明抑制某些基因可降低癌症风险。具体而言，抑制钠/葡萄糖协同转运蛋白2（SLC5A2）与头颈癌和口咽癌（OPC）风险降低相关，而抑制ATP敏感性内向整流钾通道11与口腔癌风险降低有关。此外，抑制SLC5A1和电压依赖性L型钙通道亚基β-2与降低口咽癌风险有关。这些发现表明，针对这些基因可能为预防和治疗头颈癌提供有前景的治疗策略，以及改善受影响患者的术前和术后管理。
