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分次剥脱性CO2激光叠加法治疗凹陷性瘢痕的临床疗效

Clinical efficacy of the fractional ablative CO laser stacking method for depressed scars.

作者信息

Lee Jung Hwan, Yoo Jung Hwan, Ko Jang Hyu, Song Woo Jin, Kwon Min Ju, Park Yang Seo, Lee Yun Hae, Lee Myung Chul

机构信息

Hangangsoo Plastic Surgery Clinic, Seoul, Republic of Korea.

Konkuk University Medical Center, Seoul, Republic of Korea.

出版信息

Lasers Med Sci. 2025 Feb 5;40(1):65. doi: 10.1007/s10103-025-04332-y.

DOI:10.1007/s10103-025-04332-y
PMID:39907810
Abstract

Depressed scars, which are unsightly outcomes of trauma or skin lesions, can lead to significant physical and mental stress. Various treatments have been developed to alleviate these burdens, among which the laser stacking method has proven effective. In this study, we compared the outcomes of laser stacking treatments with those of single-pulse ablative laser treatments for depressed scars. Eighty patients with depressed scars were divided into two therapeutic groups: the ablative laser stacking therapy group (Group 1, n = 40) and the single pulse ablative laser therapy group (Group 2, n = 40). The scars were evaluated using the modified Vancouver Scar Scale (mVSS) before and after treatment. Patient-completed questionnaires were also utilized. Comparative analyses were conducted both before and after treatment, as well as between the two groups. Eighty scars from each patient underwent the complete laser treatment protocols. Group 1 showed significantly greater improvement in the mVSS indices for pigmentation, vascularity, pliability, and height than group 2 (P < 0.05). In terms of patient-reported outcomes, group 1 rated better than group 2 across three indices: appearance, alleviation of concavity, and overall improvement (P < 0.05). Ablative laser stacking therapy effectively alleviated depressed scars, demonstrating significant improvement in both observer- and patient-reported outcomes. An energy level of 20-30 mJ was employed, resulting in more favorable outcomes compared to a single pulse laser application of 10-15 mJ. Our findings highlight the benefits of the stacking method, which shows notable improvements while minimizing complications. Further research involving various protocols may optimize clinical outcomes and patient satisfaction.

摘要

凹陷性瘢痕是创伤或皮肤损伤的难看后果,会导致严重的身心压力。人们已经开发出各种治疗方法来减轻这些负担,其中激光堆叠法已被证明是有效的。在本研究中,我们比较了激光堆叠治疗与单脉冲消融激光治疗凹陷性瘢痕的效果。80例凹陷性瘢痕患者被分为两个治疗组:消融激光堆叠治疗组(第1组,n = 40)和单脉冲消融激光治疗组(第2组,n = 40)。在治疗前后使用改良温哥华瘢痕量表(mVSS)对瘢痕进行评估。还使用了患者填写的问卷。在治疗前后以及两组之间进行了比较分析。每位患者的80处瘢痕都接受了完整的激光治疗方案。第1组在色素沉着、血管分布、柔韧性和高度的mVSS指数方面的改善明显大于第2组(P < 0.05)。在患者报告的结果方面,第1组在外观、凹陷减轻和总体改善这三个指标上的评分均高于第2组(P < 0.05)。消融激光堆叠疗法有效地减轻了凹陷性瘢痕,在观察者和患者报告的结果方面均显示出显著改善。采用了20 - 30 mJ的能量水平,与10 - 15 mJ的单脉冲激光应用相比,产生了更有利的结果。我们的研究结果突出了堆叠法的益处,该方法在显著改善的同时将并发症降至最低。涉及各种方案的进一步研究可能会优化临床结果和患者满意度。

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本文引用的文献

1
Efficacy of fractional CO laser therapy combined with hyaluronic acid dressing for treating facial atrophic acne scars: a systematic review and meta-analysis of randomized controlled trials.分幅 CO2 激光联合透明质酸敷料治疗面部萎缩性痤疮瘢痕的疗效:随机对照试验的系统评价和荟萃分析。
Lasers Med Sci. 2023 Sep 19;38(1):214. doi: 10.1007/s10103-023-03879-y.
2
Fractional carbon dioxide laser combined with subcision for the treatment of three subtypes of atrophic acne scars: a retrospective analysis.分比二氧化碳激光联合皮肤磨削术治疗三种类型的萎缩性痤疮瘢痕:回顾性分析。
Lasers Med Sci. 2023 Aug 28;38(1):195. doi: 10.1007/s10103-023-03851-w.
3
Improvement in linear depressed atrophic scar using 755-nm picosecond alexandrite laser vs. ablative fractional carbon dioxide laser.
755nm 皮秒翠绿宝石激光治疗线性凹陷萎缩性瘢痕的疗效优于剥脱性点阵二氧化碳激光。
J Cosmet Laser Ther. 2022 Jul 4;24(1-5):48-55. doi: 10.1080/14764172.2022.2100915. Epub 2022 Jul 21.
4
Treatment of acne scars with fractional carbon dioxide laser in Asians: a retrospective study to search for predicting factors associated with efficacy.亚洲人用分幅二氧化碳激光治疗痤疮疤痕:一项寻找与疗效相关的预测因素的回顾性研究。
Lasers Med Sci. 2022 Aug;37(6):2623-2627. doi: 10.1007/s10103-022-03528-w. Epub 2022 Feb 26.
5
Efficacy and adverse reactions of fractional CO laser for atrophic acne scars and related clinical factors: A retrospective study on 121 patients.分幅 CO2 激光治疗萎缩性痤疮瘢痕的疗效及不良反应分析及其相关临床因素:121 例患者回顾性研究。
J Cosmet Dermatol. 2022 May;21(5):1989-1997. doi: 10.1111/jocd.14868. Epub 2022 Feb 25.
6
Effects of the lower energy and pulse stacking in carbon dioxide laser skin treatment: an objective analysis using second harmonic generation.二氧化碳激光皮肤治疗中低能量和脉冲堆积的效果:基于二次谐波产生的客观分析。
Acta Cir Bras. 2021 May 7;36(3):e360304. doi: 10.1590/ACB360304. eCollection 2021.
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The efficacy of fractional ablative carbon dioxide laser combined with other therapies in acne scars.剥脱性二氧化碳点阵激光联合其他疗法治疗痤疮瘢痕的疗效。
Dermatol Ther. 2019 Nov;32(6):e13084. doi: 10.1111/dth.13084. Epub 2019 Oct 7.
8
Efficacy of Autologous Platelet-Rich Plasma Combined With Ablative Fractional Carbon Dioxide Laser for Acne Scars: A Systematic Review and Meta-Analysis.富血小板血浆联合剥脱性二氧化碳点阵激光治疗痤疮瘢痕的疗效:系统评价和荟萃分析。
Aesthet Surg J. 2019 Jun 21;39(7):NP279-NP287. doi: 10.1093/asj/sjz048.
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Ablative Fractional CO2 Laser for Facial Atrophic Acne Scars.剥脱性分数二氧化碳激光治疗面部萎缩性痤疮瘢痕
Facial Plast Surg. 2018 Apr;34(2):205-219. doi: 10.1055/s-0037-1606096. Epub 2018 Jan 5.
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Inflammatory responses, matrix remodeling, and re-epithelialization after fractional CO laser treatment of scars.二氧化碳点阵激光治疗瘢痕后的炎症反应、基质重塑和再上皮化
Lasers Surg Med. 2017 Sep;49(7):675-685. doi: 10.1002/lsm.22666. Epub 2017 May 10.