Wu Jheng-Yan, Wu Yu-Jou, Liu Mei-Yuan, Hsu Wan-Hsuan, Tsai Ya-Wen, Liu Ting-Hui, Huang Po-Yu, Chuang Min-Hsiang, Lee Mei-Chuan, Hung Kuo-Chuan, Yu Tsung, Lin Bing-Han, Liao Kuang-Ming, Lai Chih-Cheng
Department of Nutrition, Chi Mei Medical Center, Tainan, Taiwan.
Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
J Am Nutr Assoc. 2025 Aug;44(6):521-528. doi: 10.1080/27697061.2025.2461215. Epub 2025 Feb 5.
This study aimed to investigate the association between zinc deficiency (ZD) and the risks of all-cause mortality, major adverse cardiovascular events (MACEs), major adverse kidney events (MAKEs), and all-cause hospitalization in diabetic patients.
This retrospective cohort study utilized the TriNetX research network to identify adult patients with diabetes mellitus (DM) between January 1, 2010, and August 31, 2024. Propensity score matching was used to match patients with serum zinc levels below 70 µg/dL (ZD group) to those with serum zinc levels between 70 and 120 µg/dL (control group).
Each group comprised 11,698 matched patients with balanced baseline characteristics. During the 1-year follow-up period, the ZD group exhibited significantly higher risks of all-cause mortality (hazard ratio [HR]: 1.788, 95% confidence interval [CI]: 1.591-2.009), MACEs (HR: 1.641, 95% CI: 1.278-2.105), and MAKEs (HR: 1.534, 95% CI: 1.293-1.821), as well as a higher risk of hospitalization (HR: 1.272, 95% CI: 1.216-1.330).
Zinc deficiency in diabetic patients is associated with increased risks of all-cause mortality, MACEs, MAKEs, and all-cause hospitalization. These findings underscore the importance of assessing zinc status in the clinical management of patients with DM.
本研究旨在调查糖尿病患者锌缺乏（ZD）与全因死亡率、主要不良心血管事件（MACE）、主要不良肾脏事件（MAKE）以及全因住院风险之间的关联。
这项回顾性队列研究利用TriNetX研究网络，识别2010年1月1日至2024年8月31日期间的成年糖尿病患者。采用倾向评分匹配法，将血清锌水平低于70µg/dL的患者（ZD组）与血清锌水平在70至120µg/dL之间的患者（对照组）进行匹配。
每组包括11,698名匹配患者，基线特征均衡。在1年的随访期内，ZD组的全因死亡率（风险比[HR]：1.788，95%置信区间[CI]：1.591 - 2.009）、MACE（HR：1.641，95% CI：1.278 - 2.105）和MAKE（HR：1.534，95% CI：1.293 - 1.821）风险显著更高，住院风险也更高（HR：1.272，95% CI：1.216 - 1.330）。
糖尿病患者的锌缺乏与全因死亡率、MACE、MAKE和全因住院风险增加相关。这些发现强调了在糖尿病患者临床管理中评估锌状态的重要性。
