Zhou Chengzeng, Pan Jiayu, Ge Yichao, Wu Xiaodan, Wu Bin
Ocean College, Zhejiang University, Zhoushan, China.
Analysis Center of Agrobiology and Environment Sciences, Zhejiang University, Hangzhou, China.
Chem Biodivers. 2025 Jun;22(6):e202500140. doi: 10.1002/cbdv.202500140. Epub 2025 Feb 6.
Chemical investigation of the marine-derived fungus Trichoderma harzianum ZN-4 led to the isolation and identification of seven new secondary metabolites, harzianolides K-Q (1-7). The complete structures of seven new compounds were determined by high-resolution mass spectrometry and nuclear magnetic resonance spectroscopic analyses coupled with electronic circular dichroism calculations. The seven isolates were inactive as antibacterial and antitumor agents. However, harzianolides K (1), L (2), M (3) and O (5) exhibited weak to moderate anti-Pestalotiopsis theae activity with minimum inhibitory concentration values at the range of 25-100 µg/mL.
对海洋来源的哈茨木霉ZN-4进行化学研究，导致分离并鉴定出7种新的次生代谢产物，即哈茨木霉内酯K-Q（1-7）。通过高分辨率质谱、核磁共振光谱分析以及电子圆二色性计算确定了这7种新化合物的完整结构。这7种分离物作为抗菌和抗肿瘤剂没有活性。然而，哈茨木霉内酯K（1）、L（2）、M（3）和O（5）表现出弱至中等的抗茶叶炭疽病菌活性，最低抑菌浓度值在25-100μg/mL范围内。
