Jha Pankhuri, Elangovan Abbinaya, Chavan Akash Keluth, Cooper Gregory, Katz Jeffry, Cominelli Fabio, Regueiro Miguel, Mansoor Emad
Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Digestive Health Institute, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Crohns Colitis 360. 2025 Jan 24;7(1):otae062. doi: 10.1093/crocol/otae062. eCollection 2025 Jan.
Common variable immunodeficiency (CVID) predisposes patients to inflammatory bowel disease (IBD). There are limited studies characterizing adults with concomitant CVID and IBD (CVID-IBD).
Demographics, clinical courses, endoscopic findings, and disease-specific therapies were obtained in adults ≥18 years with CVID-IBD over a 5-year period.
We identified 11 patients with CVID-IBD, 6 with Crohn's disease (CD), and 5 with ulcerative colitis (UC). The presenting symptoms in 10 (91%) were abdominal pain and diarrhea. A majority of patients were diagnosed with IBD before CVID. Patients with CVID-IBD were diagnosed with CVID at an older age compared to patients with CVID only. The most prevalent endoscopic finding in CD was either erythema or erosions in the ileum, whereas in UC, it was pancolitis. One patient with CD and 1 with UC required treatment with immunomodulators to achieve remission. Three patients with CD and 2 with UC required treatment with biologics to achieve remission. Eight received intravenous immunoglobulin (IVIG) for CVID. Four patients with CD and 1 with UC were diagnosed with either leukemia or lymphoma, and the most common malignancy was chronic lymphocytic leukemia ( = 3).
This is one of few studies evaluating demographic, clinical, endoscopic, histologic features, and therapeutic management in patients with CVID-IBD. Further studies are required to elucidate long-term differences in the clinical course and treatment of patients with CVID-IBD.
普通可变免疫缺陷（CVID）使患者易患炎症性肠病（IBD）。关于合并CVID和IBD（CVID-IBD）的成人患者的研究有限。
收集了5年间年龄≥18岁的CVID-IBD成人患者的人口统计学资料、临床病程、内镜检查结果及疾病特异性治疗方法。
我们确定了11例CVID-IBD患者，其中6例为克罗恩病（CD），5例为溃疡性结肠炎（UC）。10例（91%）患者的主要症状为腹痛和腹泻。大多数患者在诊断出CVID之前就已被诊断为IBD。与仅患有CVID的患者相比，CVID-IBD患者被诊断出CVID时年龄更大。CD最常见的内镜检查发现是回肠红斑或糜烂，而UC则是全结肠炎。1例CD患者和1例UC患者需要使用免疫调节剂治疗以实现缓解。3例CD患者和2例UC患者需要使用生物制剂治疗以实现缓解。8例患者因CVID接受了静脉注射免疫球蛋白（IVIG）治疗。4例CD患者和1例UC患者被诊断出患有白血病或淋巴瘤，最常见的恶性肿瘤是慢性淋巴细胞白血病（n = 3）。
这是少数评估CVID-IBD患者的人口统计学、临床、内镜、组织学特征及治疗管理的研究之一。需要进一步研究以阐明CVID-IBD患者临床病程和治疗的长期差异。
