Hamblin T, Hough D
Br J Haematol. 1977 Jul;36(3):359-65. doi: 10.1111/j.1365-2141.1977.tb00659.x.
60 patients with chronic lymphatic leukaemia (CLL) were classified according to the immunofluorescent characteristics of their lymphocytes. A group expressing surface membrane (Sm) IgM had a significantly less aggressive disease than those expressing a mixture of SmIgM and SmIgD or those without surface immunoglobulin. The patients were older than in most comparable series and had a 2:I preponderance of women. It is suggested that especially among old ladies there is a benign variety of CLL which expresses SmIgMK, and that determination of the SmIg class in CLL has prognostic value.
根据淋巴细胞的免疫荧光特征，对60例慢性淋巴细胞白血病（CLL）患者进行了分类。表达表面膜（Sm）IgM的一组患者的疾病侵袭性明显低于表达SmIgM和SmIgD混合物的患者或无表面免疫球蛋白的患者。这些患者比大多数类似系列中的患者年龄更大，女性与男性的比例为2:1。有人提出，特别是在老年女性中，存在一种表达SmIgMk的良性CLL变种，并且在CLL中测定SmIg类别具有预后价值。
