Nielsen J, Sangö C, Winroth G, Hallberg T, Skerfving S
Scand J Work Environ Health. 1985 Feb;11(1):51-4. doi: 10.5271/sjweh.2253.
A spray-painter suffered attacks of chills, fever, general malaise, dyspnea and wheezing, headache, arthralgia, and leucocytosis a few hours after exposure to aerosols of varnishes containing two different polyisocyanates based upon monomers of hexamethylene or toluene diisocyanate. Immunologic studies revealed an increase in the serum immunoglobulin G level, but no specific antibodies against isocyanates conjugated to human serum albumin. The polyisocyanate level in the workroom air was high [a time-weighted average of 4.2 mg/m3, corresponding to 17 mumol NCO (isocyanate groups)/m3], the toluene diisocyanate monomer level being much lower (a time-weighted average of 0.03 mg/m3, corresponding to 0.3 mumol NCO/m3).
一名喷漆工在接触含有基于六亚甲基或甲苯二异氰酸酯单体的两种不同多异氰酸酯的清漆气雾剂数小时后，出现寒战、发热、全身不适、呼吸困难和喘息、头痛、关节痛以及白细胞增多。免疫学研究显示血清免疫球蛋白G水平升高，但未发现针对与人血清白蛋白结合的异氰酸酯的特异性抗体。工作场所空气中的多异氰酸酯水平很高[时间加权平均值为4.2毫克/立方米，相当于17微摩尔NCO（异氰酸酯基团）/立方米]，甲苯二异氰酸酯单体水平则低得多（时间加权平均值为0.03毫克/立方米，相当于0.3微摩尔NCO/立方米）。
