Li Shuang, Li Shuangjiang, Guan Linjing, Li Mingjuan, Zhao Jiahui, Wu Min, Li Qiuyun, Li Hui, Ouyang Guoqing, Pan Guangdong
Graduate School of Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Department of General Surgery, Liuzhou People's Hospital, Liuzhou, Guangxi, China.
Front Nutr. 2025 Jan 27;12:1510563. doi: 10.3389/fnut.2025.1510563. eCollection 2025.
The global burden of non-alcoholic steatohepatitis (NASH)-related liver cancer (NRLC) is increasing, making NASH the fastest-growing cause of liver cancer worldwide. This study presents a comprehensive analysis of NRLC burden at the global, regional, and national levels, further categorized by age, sex, and sociodemographic index (SDI).
Data on NRLC from the Global Burden of Disease, Injuries, and Risk Factors (GBD) study 2021 were downloaded at global, regional, and national levels. The numbers and age-standardized rates (ASRs) of incidence, mortality, and disability-adjusted life years (DALYs) were analyzed to quantify the global burden of NRLC. Additionally, percentage changes in ASRs were used to identify trends in NRLC from 1990 to 2021.
Globally, both the number of cases and ASRs for NRLC increased between 1990 and 2021. In 2021, there were 42,291 new cases, 40,925 deaths, and 995,475 DALYs attributed to NRLC. East Asia, South Asia, and Southeast Asia reported the highest absolute case numbers, while Western, Southern, and Eastern Sub-Saharan Africa exhibited the highest ASRs. From 1990 to 2021, Australasia, Southern Latin America, and High-income North America showed the most significant increases in NRLC incidence. Nationally, Mongolia, Gambia, and Mozambique exhibited the highest ASR in 2021.The greatest percentage increases in ASIR occurred in Australia, the United Kingdom, and New Zealand between 1990 and 2021. NRLC incidence rates were higher in men and increased with age, peaking at 80-89 years. Similar patterns were observed for NRLC-related deaths and DALYs. Regionally, ASRs initially declined but then increased as SDI rose. At the national level, ASRs consistently decreased with higher SDI.
This study highlights the substantial burden of NRLC at global, regional, and national levels. Males and older individuals bear a higher disease burden, and considerable variation exists across different regions and countries. These findings provide critical insights for formulating effective strategies to prevent and manage NRLC.
非酒精性脂肪性肝炎（NASH）相关肝癌（NRLC）的全球负担正在增加，使NASH成为全球肝癌增长最快的病因。本研究对全球、区域和国家层面的NRLC负担进行了全面分析，并按年龄、性别和社会人口指数（SDI）进一步分类。
从《2021年全球疾病、伤害和风险因素负担（GBD）研究》中下载了全球、区域和国家层面的NRLC数据。分析了发病率、死亡率和伤残调整生命年（DALY）的数量及年龄标准化率（ASR），以量化NRLC的全球负担。此外，还使用ASR的百分比变化来确定1990年至2021年期间NRLC的趋势。
在全球范围内，1990年至2021年期间，NRLC的病例数和ASR均有所增加。2021年，归因于NRLC的新发病例有42291例，死亡40925例，DALY为995475例。东亚、南亚和东南亚报告的绝对病例数最高，而撒哈拉以南非洲西部、南部和东部的ASR最高。1990年至2021年期间，澳大拉西亚、拉丁美洲南部和高收入北美地区的NRLC发病率增长最为显著。在国家层面，2021年蒙古、冈比亚和莫桑比克的ASR最高。1990年至2021年期间，澳大利亚、英国和新西兰的年龄标准化发病率（ASIR）增长百分比最大。NRLC发病率男性高于女性，且随年龄增长而增加，在80-89岁达到峰值。NRLC相关死亡和DALY也观察到类似模式。在区域层面，ASR最初下降，但随后随着SDI的上升而增加。在国家层面，ASR随着SDI的升高而持续下降。
本研究突出了全球、区域和国家层面NRLC的巨大负担。男性和老年人承担着更高的疾病负担，不同地区和国家存在相当大的差异。这些发现为制定预防和管理NRLC的有效策略提供了关键见解。
