Endophytic fungi isolated from Vietnamese nut grass ( L. Cyperaceae) - A promising solution to mitigate the prime phenomenon of antibiotic resistance.

Multidrug resistance in bacteria poses a significant threat to global health, creating an urgent need for new sources of antibiotics. Nut grass or L., a common Asian medicinal herbal remedy, is gaining increasing attention in the scientific community as a potential source of antimicrobial agents. In this study, endophytic fungi living in this plant were isolated, macro- and micrologically identified, and assessed for their antibacterial properties on both Gram-positive and Gram-negative bacteria. As a result, seven types of endophytic fungi with potential antibacterial activities were obtained from Vietnamese L. These endophytic strains could inhibit bacteria, including , (, and (. In particular, the most potent fungus could effectively inhibit not only but also and . Furthermore, a significant impact of the culture medium on the biomass' antibacterial activity was observed and the Potato Dextrose Agar (PDA) and Czapek-Dox (Cz) media were shown to be the most appropriate culture medium. Altogether, endophytic fungi isolated from L. were shown to be a promising source for antibiotics to tackle the problem of antibiotic resistance.