Nielsen G D, Olsen J, Bakbo J C, Holst E
Acta Pharmacol Toxicol (Copenh). 1985 Feb;56(2):165-75. doi: 10.1111/j.1600-0773.1985.tb01271.x.
After cessation of the sensory irritation response, described in part one (Nielsen et al. 1985), a mixed response due to pulmonary irritation and anaesthesia appeared, resulting a decrease in respiratory rate and tidal volume. The corresponding thresholds were 1490 p.p.m. and 1280 p.p.m., respectively, obtained from the last half hour of a four hours exposure period. As the decrease in respiratory rate and tidal volume was found to be correlated, the per cent decrease in respiratory minute volume could be approximated from the square of the respiratory frequency. A threshold limit value (TLV) about 100 p.p.m. based on pulmonary irritation and anaesthesia was proposed. No impurities in the technical grade ether influenced the responses.
在第一部分（尼尔森等人，1985年）所述的感觉刺激反应停止后，出现了由肺部刺激和麻醉引起的混合反应，导致呼吸频率和潮气量下降。相应的阈值分别为1490 ppm和1280 ppm，这是在四小时暴露期的最后半小时获得的。由于发现呼吸频率和潮气量的下降是相关的，呼吸分钟量的下降百分比可以通过呼吸频率的平方近似得出。基于肺部刺激和麻醉提出了约100 ppm的阈限值。工业级乙醚中的杂质不影响反应。
