Prayoga Deshanda Kurniawan, Aulifa Diah Lia, Budiman Arif, Levita Jutti, Jiranusornkul Supat
Doctoral Program in Pharmacy, Faculty of Pharmacy, Padjadjaran University, Sumedang, West Java, Indonesia.
Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Padjadjaran University, Sumedang, Indonesia.
Drug Des Devel Ther. 2025 Feb 7;19:841-856. doi: 10.2147/DDDT.S500645. eCollection 2025.
Peptic ulcer disease (PUD) remains a significant global health issue, affecting millions despite a decrease in overall prevalence. However, complications continue to persist, with substantial mortality rates in regions like India and China. Current treatments, though effective, have limitations, driving interest in plant-derived therapy. Anthocyanins, including cyanidin and cyanidin-3-glucoside (C3G), are known for their antioxidant and anti-inflammatory properties. This study aims to explore the potential of cyanidin and C3G in alleviating PUD, focusing on their mechanisms of action and therapeutic efficacy in preclinical studies. Articles were searched in Scopus and PubMed databases and filtered for publication from 2014 to 2024, resulting in 89 articles from Scopus and 11 articles from PubMed. The articles were further screened by title, abstract, and full text, resulting in 6 articles. Cyanidin and C3G were described to be able to alleviate PUD by inhibiting the cytokine pro-inflammatory, reducing inflammation in gastric mucosa, and reducing lipid peroxidation in the gastric mucosa. These compounds have proven effective in managing other health problems, including peptic ulcers, but more in-depth exploration in clinical settings is required to confirm therapeutic potential in humans. It is necessary to validate the therapeutic efficacy and safety in human populations. This review provides an overview of preclinical studies of cyanidin and C3G, such as in vitro and in vivo, focusing on mechanism of action or their effectiveness in alleviating peptic ulcers.
消化性溃疡病（PUD）仍然是一个重大的全球健康问题，尽管总体患病率有所下降，但仍影响着数百万人。然而，并发症仍然存在，在印度和中国等地区死亡率很高。目前的治疗方法虽然有效，但有局限性，这激发了人们对植物源性疗法的兴趣。花青素，包括矢车菊素和矢车菊素 - 3 - 葡萄糖苷（C3G），以其抗氧化和抗炎特性而闻名。本研究旨在探讨矢车菊素和C3G在缓解消化性溃疡病方面的潜力，重点关注其在临床前研究中的作用机制和治疗效果。在Scopus和PubMed数据库中搜索文章，并筛选2014年至2024年发表的文章，结果从Scopus获得89篇文章，从PubMed获得11篇文章。通过标题、摘要和全文对文章进行进一步筛选，最终得到6篇文章。据描述，矢车菊素和C3G能够通过抑制促炎细胞因子、减轻胃黏膜炎症以及减少胃黏膜中的脂质过氧化来缓解消化性溃疡病。这些化合物已被证明在处理包括消化性溃疡在内的其他健康问题方面有效，但需要在临床环境中进行更深入的探索，以确认其对人类的治疗潜力。有必要在人群中验证其治疗效果和安全性。本综述概述了矢车菊素和C3G的临床前研究，如体外和体内研究，重点关注其作用机制或在缓解消化性溃疡方面的有效性。
