Graduating in biomedicine at the Christus University Center - UNICHRISTUS, Fortaleza, CE, Brazil.
Master in Public Health from the Federal University of Ceará - UFC, Fortaleza, CE, Brazil.
JBRA Assist Reprod. 2023 Sep 12;27(3):496-506. doi: 10.5935/1518-0557.20230006.
The vaginal microbiome is dominated by Lactobacillus spp. and the depletion of these microorganisms have been associated with adverse conditions that can affect women's health. Disturbance of the vaginal niche with a non-lactobacillary microbiota is associated with susceptibility to some diseases, such as obstetric alterations and infertility, resulting in failure in natural pregnancies and increased demand for assisted reproduction treatments. The present study sought to understand the influence of Lactobacillus spp. and fertility female. A systematic search was performed in the following databases: PubMed, MEDLINE, SciELO and LILACS, using the keywords: "Microbiome"; "Lactobacillus" and "Female Infertility", published in the last five years. The search resulted in 92 articles; however, 38 articles were excluded due to duplicity, 23 articles were excluded in the selection title/abstract, leaving 31 articles for full reading. In the end, 18 articles were analyzed. The studies encompassed a total of 2,011 women, using 27 types of samples to verify the composition of the microbiome. The eighteen articles that reported the microbiome of fertile women were constituted by a dominance of Lactobacillus spp. who joined to positive predictive outcomes in reproduction, while infertile women showed a dysbiotic profile. Therefore, analyzing bacterial patterns would allow a personalized diagnosis, which could favor personalized therapy for prevention and treatment of certain diseases.
阴道微生物群主要由乳杆菌属组成，这些微生物的消耗与可能影响女性健康的不利条件有关。阴道生态位的紊乱与非乳杆菌菌群有关，与一些疾病的易感性有关，如产科改变和不孕，导致自然妊娠失败和对辅助生殖治疗的需求增加。本研究旨在了解乳杆菌属和生育力对女性的影响。在以下数据库中进行了系统搜索：PubMed、MEDLINE、SciELO 和 LILACS，使用的关键词是：“微生物组”；“乳杆菌”和“女性不孕”，在过去五年中发表。搜索结果有 92 篇文章；然而，由于重复，有 38 篇文章被排除，有 23 篇文章在标题/摘要选择中被排除，只有 31 篇文章进行了全文阅读。最后，分析了 18 篇文章。这些研究共纳入了 2011 名女性，使用了 27 种样本来验证微生物组的组成。报道了生育力女性微生物组的 18 篇文章显示，乳杆菌属占主导地位，与生殖方面的阳性预测结果相关，而不孕女性则表现出生态失调的特征。因此，分析细菌模式可以进行个性化诊断，从而有利于针对某些疾病的个性化预防和治疗。
