Jha H C, von Recklinghausen G, Zilliken F
Biochem Pharmacol. 1985 May 1;34(9):1367-9. doi: 10.1016/0006-2952(85)90672-0.
In a comparative study the inhibition of microsomal lipid peroxidation induced by an Fe2+-ADP-complex and NADPH by naturally occurring isoflavones and their reduced derivatives (isoflavanones and isoflavans) has been examined. It is found that the isoflavanones are more active than the parent isoflavones and the isoflavans are by far the most potent inhibitors. In our in vitro test system 6,7,4'-trihydroxy- and 6,7-dihydroxy-4'-methoxyisoflavans (IC50 values 1.3 X 10(-6) and 1.1 X 10(-6) mol/l respectively) surpass the inhibitory effect of alpha-tocopherol, (+)-cyanidanol-3 and BHA (butylated hydroxyanisole). In order to establish a structure-activity relationship, a few more isoflavans have been included in the investigation.
在一项比较研究中，考察了天然存在的异黄酮及其还原衍生物（异黄烷酮和异黄酮）对Fe2+-ADP复合物和NADPH诱导的微粒体脂质过氧化的抑制作用。发现异黄烷酮比母体异黄酮更具活性，而异黄酮是迄今为止最有效的抑制剂。在我们的体外测试系统中，6,7,4'-三羟基和6,7-二羟基-4'-甲氧基异黄酮（IC50值分别为1.3×10(-6)和1.1×10(-6)mol/l）超过了α-生育酚、(+)-儿茶素-3和BHA（丁基羟基茴香醚）的抑制作用。为了建立构效关系，在研究中又纳入了一些异黄酮。
